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It has been 10 years since our University of TennesseeDepartment of Family Medicine group reported a significant presence of bipolar disorders in primary care.In that study,1 close examination of a consecutive cohortof primarily depressive and anxious patients found 26%had bipolar disorders—usually bipolar II disorder. Twoyears later, in the inaugural issue of the Companion, wereported on a group of patients with difficult-to-treat depressionseen in our mood disorders clinics.2