The Tolerability of Oral-Loaded Valproate After Remission of Acute Mania in Japanese Patients With Bipolar Disorder

Kiyomi Shinohara, MD; Yasumasa Okamoto, MD, PhD; Hiroaki Jitsuiki, MD, PhD; Hidehisa Yamashita, MD, PhD; Shigeru Morinobu, MD, PhD; Shigeto Yamayaki, MD, PhD

Prim Care Companion J Clin Psychiatry 2007;9(3):241

Abstract

Article Abstract

Because this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: A patient presented to us having experienced a fewdays of massive epistaxis and hyposphagma (severe hemorrhageinto the conjunctiva) while taking paroxetine. Pharmaceuticaluse was also notable for the peripheral vasodilatorlimaprost alfadex. To our knowledge, no such case has been reportedin the literature.