Quetiapine-Induced Hypersalivation

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Sir: Quetiapine fumarate is a dibenzothiazepinederivativeantipsychotic with combined antagonism atdopamine (D1, D2) and serotonin type 1 and type 2 (5-HT_1A,5-HT_2A, 5-HT_2C) receptors. Additionally, quetiapine antagonizesα₁– and α₂-adrenergic andhistamine H₁ receptors.Protean binding at the above receptors explains thecommon side effects, which include hypersomnolence,hypotension, headache, weight gain, and gastrointestinaldisturbance.