Oxcarbazepine in Bipolar Disorder

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Sir: Dr. Berigan’s otherwise thorough overview of neweranticonvulsants in psychiatry¹ requires comment with regard tooxcarbazepine. The first double-blind study was placebo controlledand published in 1983, not 1985.² Six rather than 7 patientswere involved (1 was treated on 2 occasions, making atotal of 7 trials) in an A-B-A crossover design of unspecifiedduration with a mean improvement in Inpatient MultidimensionalPsychiatric Scale scores of 49.9%, not 86%.