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Erectile dysfunction and depression are common medical conditions and frequently coexist. Fifty-two percent of men aged 40 to 70 years may be expected to have some degree of erectile dysfunction (mild, moderate, or complete), including 10% with complete erectile dysfunction (total absence of erections).1 Lifetime prevalence estimates of 16% for major depression and 10% for minor depression, determined from a nationally representative survey of persons aged 15 to 54 years living in the United States, suggest that depression is also highly prevalent.2