Aripiprazole as the Causative Agent of Neuroleptic Malignant Syndrome

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Sir: Neuroleptic malignant syndrome (NMS) is a rare and potentially life-threatening neurologic emergency commonly associated with the use of antipsychotic medications. As a class, atypical antipsychotic agents have lower associated rates of extrapyramidal symptoms and are less likely to induce NMS as compared to conventional antipsychotics. One of the newest agents in the atypical antipsychotic class is aripiprazole