Weight Gain, Sexual Dysfunction, and Bupropion

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Sir: In their recent (May 2005) article, Zimmerman et al.¹reported that bupropion is not associated with weight gainor sexual dysfunction. I disagree with their assertion for thefollowing reasons.

Concerning weight gain, the package insert for bupropionextended-release (XL)² states that 9% of patients treated withthe immediate-release (IR) form of bupropion gained weight,a rate higher than that found with placebo.