Vagus Nerve Stimulation Improves Restless Legs Syndrome Associated With Major Depression: A Case Report

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Sir: Vagus nerve stimulation (VNS) has shown effects in treatment-resistant epilepsy¹ and major depressive episode.² Epidemiologic studies have described restless legs syndrome (RLS) to exist in varying degrees of severity in 2.5% to 10% of the population.³ Treatment of first choice is dopamine agonists, but agents that enhance inhibitory mechanisms in the way that anticonvulsive drugs do are effective, too.' ‹