A 100-Year Update on Alzheimer's Disease and Related Disorders

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This month marks the 100th anniversary of the scientific presentation in which Dr. Alois Alzheimer described the clinical and neuropathologic features of the disease that now bears his name.^1,2 In this issue of The Journal of Clinical Psychiatry, our "Focus on Alzheimer's Disease and Related Disorders" section commemorates this historic event with the publication of a review article on Alzheimer's disease. Richard Caselli, Thomas Beach, Roy Yaari, and I consider the clinical and neuropathologic features, evaluation, and management of Alzheimer's disease; known genetic risk factors and suggested pathogenic mechanisms; and some of the promising disease slowing and prevention strategies that remain to be rigorously tested.' ‹' ‹