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Author Affiliations
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Addiction Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Addiction Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Addiction Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, King AbdulAziz University, Jeddah, Saudi Arabia
Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Corresponding Author: Ahmed N. Hassan, MD, FRCPC, 100 Stokes St, Toronto, ON M6J 1H4 ([email protected]).
References (72)
Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. PubMedCrossRef
Koenen KC, Ratanatharathorn A, Ng L, et al. Posttraumatic stress disorder in the World Mental Health Surveys. Psychol Med. 2017;47(13):2260–2274. PubMedCrossRef
Goldstein RB, Smith SM, Chou SP, et al. The epidemiology of DSM-5 posttraumatic stress disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Soc Psychiatry Psychiatr Epidemiol. 2016;51(8):1137–1148. PubMedCrossRef
Janoutová J, Janácková P, Serý O, et al. Epidemiology and risk factors of schizophrenia. Neuroendocrinol Lett. 2016;37(1):1–8. PubMed
Rowland TA, Marwaha S. Epidemiology and risk factors for bipolar disorder. Ther Adv Psychopharmacol. 2018;8(9):251–269. PubMedCrossRef
Krysinska K, Lester D. Post-traumatic stress disorder and suicide risk: a systematic review. Arch Suicide Res. 2010;14(1):1–23. PubMedCrossRef
Rapaport MH, Clary C, Fayyad R, et al. Quality-of-life impairment in depressive and anxiety disorders. Am J Psychiatry. 2005;162(6):1171–1178. PubMedCrossRef
Pietrzak RH, Goldstein RB, Southwick SM, et al. Medical comorbidity of full and partial posttraumatic stress disorder in US adults: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosom Med. 2011;73(8):697–707. PubMedCrossRef
McCauley JL, Killeen T, Gros DF, et al. Posttraumatic stress disorder and co-occurring substance use disorders: advances in assessment and treatment. Clin Psychol (New York). 2012;19(3):283–304. PubMedCrossRef
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5-TR. Fifth Edition, Text Revision. American Psychiatric Association Publishing; 2022.
Stein DJ, Ipser JC, Seedat S. Pharmacotherapy for post traumatic stress disorder (PTSD). Cochrane Database Syst Rev. 2006;2006(1):CD002795. PubMedCrossRef
Lewis C, Roberts NP, Gibson S, et al. Dropout from psychological therapies for post-traumatic stress disorder (PTSD) in adults: systematic review and meta-analysis. Eur J Psychotraumatol. 2020;11(1):1709709. PubMedCrossRef
Hill MN, Campolongo P, Yehuda R, et al. Integrating endocannabinoid signaling and cannabinoids into the biology and treatment of posttraumatic stress disorder. Neuropsychopharmacology. 2018;43(1):80–102. PubMedCrossRef
Hillard CJ, Weinlander KM, Stuhr KL. Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience. 2012;204:207–229. PubMedCrossRef
Ney LJ, Matthews A, Bruno R, et al. Cannabinoid interventions for PTSD: where to next? Prog Neuropsychopharmacol Biol Psychiatry. 2019;93:124–140. PubMedCrossRef
Ruehle S, Rey AA, Remmers F, et al. The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol. 2012;26(1):23–39. PubMedCrossRef
Ganon-Elazar E, Akirav I. Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci. 2009;29(36):11078–11088. PubMedCrossRef
Maldonado R, Cabañero D, Martín-García E. The endocannabinoid system in modulating fear, anxiety, and stress . Dialogues Clin Neurosci. 2020;22(3):229–239. PubMedCrossRef
Marsicano G, Wotjak CT, Azad SC, et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature. 2002;418(6897):530–534. PubMedCrossRef
Niyuhire F, Varvel SA, Martin BR, et al. Exposure to marijuana smoke impairs memory retrieval in mice. J Pharmacol Exp Ther. 2007;322(3):1067–1075. PubMedCrossRef
Blessing EM, Steenkamp MM, Manzanares J, et al. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics. 2015;12(4):825–836. PubMedCrossRef
Neumeister A, Normandin MD, Pietrzak RH, et al. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Mol Psychiatry. 2013;18(9):1034–1040. PubMedCrossRef
Lake S, Kerr T, Buxton J, et al. Does cannabis use modify the effect of post-traumatic stress disorder on severe depression and suicidal ideation? evidence from a population-based cross-sectional study of Canadians. J Psychopharmacol. 2020;34(2):181–188. PubMedCrossRef
Bilevicius E, Sommer JL, Asmundson GJG, et al. Associations of PTSD, chronic pain, and their comorbidity on cannabis use disorder: results from an American nationally representative study. Depress Anxiety. 2019;36(11):1036–1046. PubMedCrossRef
Moher D, Liberati A, Tetzlaff J, et al; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. PubMedCrossRef
Sterne JAC, Hernán MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919. PubMedCrossRef
Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. PubMedCrossRef
Vardell E, Malloy M. Joanna Briggs Institute: an evidence-based practice database. Med Ref Serv Q. 2013;32(4):434–442. PubMedCrossRef
Bonn-Miller MO, Brunstetter M, Simonian A, et al. The long-term, prospective, therapeutic impact of cannabis on post-traumatic stress disorder. Cannabis Cannabinoid Res. 2022;7(2):214–223. PubMedCrossRef
Cameron C, Watson D, Robinson J. Use of a synthetic cannabinoid in a correctional population for posttraumatic stress disorder-related insomnia and nightmares, chronic pain, harm reduction, and other indications: a retrospective evaluation. J Clin Psychopharmacol. 2014;34(5):559–564. PubMedCrossRef
Elms L, Shannon S, Hughes S, et al. Cannabidiol in the treatment of post-traumatic stress disorder: a case series. J Altern Complement Med. 2019;25(4):392–397. PubMedCrossRef
Greer GR, Grob CS, Halberstadt AL. PTSD symptom reports of patients evaluated for the New Mexico Medical Cannabis Program. J Psychoactive Drugs. 2014;46(1):73–77. PubMedCrossRef
Pillai M, Erridge S, Bapir L, et al. Assessment of clinical outcomes in patients with post-traumatic stress disorder: analysis from the UK Medical Cannabis Registry. Expert Rev Neurother. 2022;22(11-12):1009–1018. PubMedCrossRef
Allan NP, Ashrafioun L, Kolnogorova K, et al. Interactive effects of PTSD and substance use on suicidal ideation and behavior in military personnel: Increased risk from marijuana use. Depress Anxiety. 2019;36(11):1072–1079. PubMedCrossRef
Wilkinson ST, Stefanovics E, Rosenheck RA. Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder. J Clin Psychiatry. 2015;76(9):1174–1180. PubMedCrossRef
Johnson MJ, Pierce JD, Mavandadi S, et al. Mental health symptom severity in cannabis using and non-using veterans with probable PTSD. J Affect Disord. 2016;190:439–442. PubMedCrossRef
Roitman P, Mechoulam R, Cooper-Kazaz R, et al. Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Clin Drug Investig. 2014;34(8):587–591. PubMedCrossRef
Bonn-Miller MO, Sisley S, Riggs P, et al. The short-term impact of 3 smoked cannabis preparations versus placebo on PTSD symptoms: a randomized cross-over clinical trial. PLoS One. 2021;16(3):e0246990. PubMedCrossRef
Bonn-Miller MO, Boden MT, Vujanovic AA, et al. Prospective investigation of the impact of cannabis use disorders on posttraumatic stress disorder symptoms among veterans in residential treatment. Psychol Trauma. 2013;5(2):193–200. CrossRef
Livingston NA, Farmer SL, Mahoney CT, et al. Longitudinal course of mental health symptoms among veterans with and without cannabis use disorder. Psychol Addict Behav. 2022;36(2):131–143. PubMedCrossRef
Manhapra A, Stefanovics E, Rosenheck R. Treatment outcomes for veterans with PTSD and substance use: impact of specific substances and achievement of abstinence. Drug Alcohol Depend. 2015;156:70–77. PubMedCrossRef
Jetly R, Heber A, Fraser G, et al. The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: a preliminary randomized, double-blind, placebo-controlled cross-over design study. Psychoneuroendocrinology. 2015;51:585–588. PubMedCrossRef
Botsford SL, Yang S, George TP. Cannabis and cannabinoids in mood and anxiety disorders: impact on illness onset and course, and assessment of therapeutic potential. Am J Addict. 2020;29(1):9–26. PubMedCrossRef
Rehman Y, Saini A, Huang S, et al. Cannabis in the management of PTSD: a systematic review. AIMS Neurosci. 2021;8(3):414–434. PubMedCrossRef
Wilkinson ST, Radhakrishnan R, D’Souza DC. A systematic review of the evidence for medical marijuana in psychiatric indications. J Clin Psychiatry. 2016;77(8):1050–1064. PubMedCrossRef
Steenkamp MM, Blessing EM, Galatzer-Levy IR, et al. Marijuana and other cannabinoids as a treatment for posttraumatic stress disorder: a literature review. Depress Anxiety. 2017;34(3):207–216. PubMedCrossRef
LaFrance EM, Glodosky NC, Bonn-Miller M, et al. Short and long-term effects of cannabis on symptoms of post-traumatic stress disorder. J Affect Disord. 2020;274:298–304. PubMedCrossRef
Feinberg I, Jones R, Walker JM, et al. Effects of high dosage delta-9-tetrahydrocannabinol on sleep patterns in man. Clin Pharmacol Ther. 1975;17(4):458–466. PubMedCrossRef
Feinberg I, Jones R, Walker J, et al. Effects of marijuana extract and tetrahydrocannabinol on electroencephalographic sleep patterns. Clin Pharmacol Ther. 1976;19(6):782–794. PubMedCrossRef
Schierenbeck T, Riemann D, Berger M, et al. Effect of illicit recreational drugs upon sleep: cocaine, ecstasy and marijuana. Sleep Med Rev. 2008;12(5):381–389. PubMedCrossRef
Bolla KI, Lesage SR, Gamaldo CE, et al. Sleep disturbance in heavy marijuana users. Sleep. 2008;31(6):901–908. PubMedCrossRef
Ross RJ, Ball WA, Dinges DF, et al. Rapid eye movement sleep disturbance in posttraumatic stress disorder. Biol Psychiatry. 1994;35(3):195–202. PubMedCrossRef
Singareddy RK, Balon R. Sleep in posttraumatic stress disorder. Ann Clin Psychiatry. 2002;14(3):183–190. PubMedCrossRef
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. Includes ICD-9-CM Codes Effective October 1, 1996. Fourth Edition. 1998.
Weathers FW, Bovin MJ, Lee DJ, et al. The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5): development and initial psychometric evaluation in military veterans. Psychol Assess. 2018;30(3):383–395. PubMedCrossRef
Gradus JL, Qin P, Lincoln AK, et al. Posttraumatic stress disorder and completed suicide. Am J Epidemiol. 2010;171(6):721–727. PubMedCrossRef
Sher L. Neurobiology of suicidal behavior in post-traumatic stress disorder. Expert Rev Neurother. 2010;10(8):1233–1235. PubMedCrossRef
Vinod KY. Role of the endocannabinoid system in the neurobiology of suicide. In: Dwivedi Y, ed. The Neurobiological Basis of Suicide. CRC Press/Taylor & Francis; 2012.
Hungund BL, Vinod KY, Kassir SA, et al. Upregulation of CB1 receptors and agonist-stimulated [35S]GTPgammaS binding in the prefrontal cortex of depressed suicide victims. Mol Psychiatry. 2004;9(2):184–190. PubMedCrossRef
Pava MJ, den Hartog CR, Blanco-Centurion C, et al. Endocannabinoid modulation of cortical up-states and NREM sleep. PLoS One. 2014;9(2):e88672. PubMedCrossRef
Chagas MH, Crippa JA, Zuardi AW, et al. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. J Psychopharmacol. 2013;27(3):312–316. PubMedCrossRef
Hsiao YT, Yi PL, Li CL, et al. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. Neuropharmacology. 2012;62(1):373–384. PubMedCrossRef
Bitencourt RM, Takahashi RN. Cannabidiol as a therapeutic alternative for post-traumatic stress disorder: from bench research to confirmation in human trials. Front Neurosci. 2018;12:502. PubMedCrossRef
Carabellese F, Candelli C, Martinelli D, et al. Cannabis use and violent behaviour: a psychiatric patients cohort study in southern Italy. Riv Psichiatr. 2013;48(1):43–50. PubMed
Norström T, Rossow I. Cannabis use and violence: is there a link? Scand J Public Health. 2014;42(4):358–363. PubMedCrossRef
Sorkhou M, Johnstone S, Kivlichan AE, et al. Does cannabis use predict aggressive or violent behavior in psychiatric populations? a systematic review. Am J Drug Alcohol Abuse. 2022;48(6):631–643. PubMedCrossRef
Dellazizzo L, Potvin S, Dou BY, et al. Association between the use of cannabis and physical violence in youths: a meta-analytical investigation. Am J Psychiatry. 2020;177(7):619–626. PubMedCrossRef
Bayrakçı A, Sert E, Zorlu N, et al. Facial emotion recognition deficits in abstinent cannabis dependent patients. Compr Psychiatry. 2015;58:160–164. PubMedCrossRef
Castro-Vale I, Severo M, Carvalho D. Lifetime PTSD is associated with impaired emotion recognition in veterans and their offspring. Psychiatry Res. 2020;284:112666. PubMedCrossRef
Zimmermann K, Walz C, Derckx RT, et al. Emotion regulation deficits in regular marijuana users. Hum Brain Mapp. 2017;38(8):4270–4279. PubMedCrossRef