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Working in Boston in the late 1980s, I received a telephonecall from Byram Karasu, M.D. Byram was to chair the workgroupwriting the American Psychiatric Association’s (APA)first Practice Guideline for the Treatment of Patients WithMajor Depressive Disorder (MDD) and honored me with aninvitation to join. The first MDD Guideline was publishedin 1993. Byram chaired the workgroup that prepared the secondedition, which was published in 2000.’ ‹