Resolution of Fluoxetine-Induced Sexual Dysfunction With the 5-HT3 Antagonist Granisetron

Letter to the Editor

Sir: Sexual dysfunction is a common and troubling side effect of serotonin reuptake inhibitors (SRIs). The incidence of sexual dysfunction associated with SRIs has been estimated to be as high as 34%. The mechanism underlying sexual dysfunction associated with SRIs has not been fully characterized, but is thought to be partly mediated by direct serotonergic effects.