Reply to "Possible Bipolar Nature of Irritability in Major Depressive Disorder."

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Sir: In his letter, Dr. Benazzi provides an important additionto his previous work,^1-3 as well as our own,^4,5 suggesting thatmany bipolar subjects experience substantial irritability duringdepressive episodes. We would, however, emphasize 2 additionalaspects of these studies.First, to refer to the "bipolar nature of irritability" is to neglectthe observation, in his study cohort and our own, thatroughly 40% of major depressive disorder (MDD) subjects alsoexperienced irritability.’ ‹