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Sir: We are grateful to have been given the opportunity to reply to the letter by Karagianis and Dunayevich. We by all means agree that a cross-sectional study has limitations in its design. Our study should be considered as a first attempt to document the metabolic risk profile of patients who had been exposed for the same period of time to 2 atypical antipsychotics: olanzapine and risperidone.' ‹