Propofol for Severe, Refractory Mania: A Case Report

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Sir: Treatment options for severe refractory mania are limited.¹ We present our experience with a patient whose severe, refractory mania was unresponsive to electroconvulsive therapy (ECT), but whose clinical course eventually improved following the initiation of propofol. The literature has sparse documentation of the use of propofol in this setting,² but this sedative-hypnotic agent was used safely and effectively in our experience.' ‹