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Earlier, we reviewed the concept that treatments that reduce symptoms in psychiatry could also be disease modifying.1 Now comes further evidence that this pretreatment may be possible in schizophrenia,2-7 where it is already known that atypical antipsychotics not only get you better by treating acute symptoms, but also keep you better by preventing relapse.2,8 Is it possible that giving these agents to high-risk individuals with prodromal symptoms could prevent or delay progression to schizophrenia?