Prolonged Erections Associated With Ziprasidone Treatment: A Case Report

Letter to the Editor

Sir: The ischemic form of priapism (previously known as low-flow priapism) is a rare but well-recognized complication of antipsychotic agents resulting from their α₁-adrenergic blocking action. Several cases have been documented with conventional antipsychotics, especially the phenothiazines. Of the first 4 novel antipsychotics approved by the U.S. Food and Drug Administration for the treatment of psychosis, clozapine, risperidone, and olanzapine have been associated with priapism in various case reports, whereas quetiapine thus far has not.