A Pilot Observational Crossover Study of QTc Interval Changes Associated With Switching Between Olanzapine and Risperidone

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Sir: Antipsychotic drug-related QTc interval prolongations^1-3 have raised concern because of the potential risk of predisposing patients to torsade de pointes and sudden death.⁴ Olanzapine and risperidone seem to have similar safety in regard to QTc interval prolongations in clinical trials^5-7 and a head-to-head randomized comparison study.⁸ However, risperidone has been reported to be associated with cases of QT prolongation and sudden death.^9-12‘ ‹