Schizophrenia is a severe, lifelong disorder that affects cognitive, behavioral, and emotional functioning. Many individuals living with schizophrenia experience numerous relapses and ongoing impairment. To improve the clinical and functional outcomes for people with schizophrenia, clinicians should recognize the importance of adopting a patient-centered approach to treatment. Simplifying the medication regimen, using shared decision-making, and offering psychosocial interventions are strategies that may contribute to better outcomes.