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  1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  2. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  3. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  4. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  5. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  6. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  7. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  8. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  9. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  10. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  11. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
  12. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  13. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  14. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  15. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  16. Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
  17. Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
  18. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  19. Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
  20. Corresponding author: Ya-Mei Bai, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Rd, Sec 2, 11217, Taipei, Taiwan ([email protected]).
  1. Lack CW. Obsessive-compulsive disorder: Evidence-based treatments and future directions for research. World J Psychiatry. 2012;2(6):86–90. PubMed CrossRef
  2. Goodman WK, Grice DE, Lapidus KA, et al. Obsessive-compulsive disorder. Psychiatr Clin North Am. 2014;37(3):257–267. PubMed CrossRef
  3. Murray CJ, Lopez AD. The incremental effect of age-weighting on YLLs, YLDs, and DALYs: a response. Bull World Health Organ. 1996;74(4):445–446. PubMed
  4. Baxter AJ, Vos T, Scott KM, et al. The global burden of anxiety disorders in 2010. Psychol Med. 2014;44(11):2363–2374. PubMed CrossRef
  5. Isomura K, Brander G, Chang Z, et al. Metabolic and cardiovascular complications in obsessive-compulsive disorder: a total population, sibling comparison study with long-term follow-up. Biol Psychiatry. 2018;84(5):324–331. PubMed CrossRef
  6. Bralten J, Widomska J, Witte W, et al. Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling. Transl Psychiatry. 2020;10(1):121. PubMed CrossRef
  7. Albert U, Aguglia A, Chiarle A, et al. Metabolic syndrome and obsessive-compulsive disorder: a naturalistic Italian study. Gen Hosp Psychiatry. 2013;35(2):154–159. PubMed CrossRef
  8. Dondu A, Sevincoka L, Akyol A, et al. Is obsessive-compulsive symptomatology a risk factor for Alzheimer-type dementia? Psychiatry Res. 2015;225(3):381–386. PubMed CrossRef
  9. Mrabet Khiari H, Achouri A, Ben Ali N, et al. Obsessive-compulsive disorder: a new risk factor for Alzheimer disease? Neurol Sci. 2011;32(5):959–962. PubMed CrossRef
  10. Cheng CM, Chang WH, Chen MH, et al. Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study. Mol Psychiatry. 2018;23(8):1756–1763. PubMed CrossRef
  11. Chen MH, Lan WH, Hsu JW, et al. Risk of developing type 2 diabetes in adolescents and young adults with autism spectrum disorder: a nationwide longitudinal study. Diabetes Care. 2016;39(5):788–793. PubMed CrossRef
  12. Chen MH, Pan TL, Li CT, et al. Risk of stroke among patients with post-traumatic stress disorder: nationwide longitudinal study. Br J Psychiatry. 2015;206(4):302–307. PubMed CrossRef
  13. Chen MH, Hsu JW, Huang KL, et al. Sexually transmitted infection among adolescents and young adults with attention-deficit/hyperactivity disorder: a nationwide longitudinal study. J Am Acad Child Adolesc Psychiatry. 2018;57(1):48–53. PubMed CrossRef
  14. Tsai MS, Li HY, Huang CG, et al. Risk of Alzheimer’s disease in obstructive sleep apnea patients with or without treatment: real-world evidence. Laryngoscope. 2020;130(9):2292–2298. PubMed CrossRef
  15. Chen KC, Chung CH, Lu CH, et al. Association between the use of dipeptidyl peptidase 4 inhibitors and the risk of dementia among patients with type 2 diabetes in Taiwan. J Clin Med. 2020;9(3):660. PubMed CrossRef
  16. Liu CY, Hung YT, Chuang YL, et al. Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. J Health Management (Chin). 2006;4:1–22.
  17. Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383. PubMed CrossRef
  18. Chen H, Cohen P, Chen S. How big is a big odds ratio? interpreting the magnitudes of odds ratios in epidemiological studies. Commun Stat Simul Comput. 2010;39(4):860–864. CrossRef
  19. Azuero A. A note on the magnitude of hazard ratios. Cancer. 2016;122(8):1298–1299. PubMed CrossRef
  20. Frydman I, Ferreira-Garcia R, Borges MC, et al. Dementia developing in late-onset and treatment-refractory obsessive-compulsive disorder. Cogn Behav Neurol. 2010;23(3):205–208. PubMed CrossRef
  21. Roth RM, Milovan D, Baribeau J, et al. Neuropsychological functioning in early- and late-onset obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 2005;17(2):208–213. PubMed CrossRef
  22. Segalàs C, Alonso P, Labad J, et al. Verbal and nonverbal memory processing in patients with obsessive-compulsive disorder: its relationship to clinical variables. Neuropsychology. 2008;22(2):262–272. PubMed CrossRef
  23. Chu CS, Chou PH, Lin CH, et al. Use of selective serotonin reuptake inhibitors and risks of stroke in patients with obsessive compulsive disorder: a population-based study. PLoS One. 2016;11(9):e0162239. PubMed CrossRef
  24. Dondé C, Lepetit A, Dorey JM, et al. Late-life atypical reactivation of obsessive-compulsive disorder associated with frontotemporal dementia. Rev Neurol (Paris). 2019;175(3):205–206. PubMed CrossRef
  25. Podcasy JL, Epperson CN. Considering sex and gender in Alzheimer disease and other dementias. Dialogues Clin Neurosci. 2016;18(4):437–446. PubMed CrossRef
  26. Segalàs C, Alonso P, Labad J, et al. A case-control study of sex differences in strategic processing and episodic memory in obsessive-compulsive disorder. Compr Psychiatry. 2010;51(3):303–311. PubMed CrossRef
  27. Potvin O, Hudon C, Dion M, et al. Anxiety disorders, depressive episodes and cognitive impairment no dementia in community-dwelling older men and women. Int J Geriatr Psychiatry. 2011;26(10):1080–1088. PubMed CrossRef
  28. Gannon OJ, Robison LS, Custozzo AJ, et al. Sex differences in risk factors for vascular contributions to cognitive impairment & dementia. Neurochem Int. 2019;127:38–55. PubMed CrossRef
  29. Melia CS, Soria V, Salvat-Pujol N, et al. Sex-specific association between the cortisol awakening response and obsessive-compulsive symptoms in healthy individuals. Biol Sex Differ. 2019;10(1):55. PubMed CrossRef
  30. Fries E, Dettenborn L, Kirschbaum C. The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol. 2009;72(1):67–73. PubMed CrossRef
  31. Karthik S, Sharma LP, Narayanaswamy JC. Investigating the role of glutamate in obsessive-compulsive disorder: current perspectives. Neuropsychiatr Dis Treat. 2020;16:1003–1013. PubMed CrossRef
  32. Andreoli V, De Marco EV, Trecroci F, et al. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer’s disease. J Neural Transm (Vienna). 2014;121(5):533–542. PubMed
  33. Duerson K, Woltjer RL, Mookherjee P, et al. Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer’s disease patients. Brain Pathol. 2009;19(2):267–278. PubMed CrossRef
  34. Zamanian-Azodi M, Rezaei-Tavirani M, Nejadi N, et al. Serum proteomic profiling of obsessive-compulsive disorder, washing subtype: a preliminary study. Basic Clin Neurosci. 2017;8(4):307–316. PubMed CrossRef
  35. Tien YT, Lee WJ, Liao YC, et al. Plasma transthyretin as a predictor of amnestic mild cognitive impairment conversion to dementia. Sci Rep. 2019;9(1):18691. PubMed CrossRef
  36. Azodi MZ, Tavirani MR, Oskouie AA, et al. Introducing transthyretin as a differentially expressed protein in washing subtype of obsessive-compulsive disorder. Basic Clin Neurosci. 2018;9(3):187–194. PubMed CrossRef
  37. Lin JC, Lin CS, Hsu CW, et al. Association between Parkinson’s disease and inflammatory bowel disease: a nationwide Taiwanese retrospective cohort study. Inflamm Bowel Dis. 2016;22(5):1049–1055. PubMed CrossRef