Access icon

This article is freely available to all


Article Abstract

Letter to the Editor

Sir: Central nervous system (CNS) reactions have been associated with histamine H2 blocker use. Of the 78 cases of H2 blocker-associated CNS disturbances reported in the literature, 63 cases occurred with cimetidine, 13 with ranitidine, and 2 with famotidine. Thus far, no cases of nizatidine-associated CNS toxicity have been cited. The following case report describes a patient in which nizatidine maintenance induced symptoms of delirium.