Newer Medications for Complicated Depression

Available antidepressant medications are safe and moderately effective for most patients, but their overall efficacy is similar and underwhelming. The most recently developed antidepressants are either stereoisomers or metabolites of older drugs or belong to an existing class of antidepressants. The development of new medications with novel mechanisms of action and increased efficacy is needed to address unmet needs in the pharmacotherapy of depression.