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This book is the second edition of an outstanding text that extensively updates and revises the first edition, integrating the new findings that have occurred since the earlier edition was published in 1989. It provides a framework for understanding, diagnosing, treating, and preventing the often poorly understood and frequently overlapping disorders of neuroleptic malignant syndrome (NMS) and related conditions. This text reviews all of the serious hyperthermic reactions encountered in the treatment of psychiatric disorders including NMS, neuroleptic-induced heatstroke, serotonin syndrome, hyperthermic reactions associated with other pharmacologic agents, and malignant catatonia.