Nefazodone-Associated Subjective Complaints of Burning Sensations

Letter to the Editor

Sir:

Nefazodone is a relatively new antidepressant drug.Preclinical data suggest that it has potent antagonistic effects onpostsynaptic serotonin-2 (5-HT₂) receptors and moderate presynapticserotonin and norepinephrine reuptake inhibiting propertieswhile demonstrating low affinity for other receptor types(including other 5-HT receptors and cholinergic, a-adrenergic,dopaminergic, and histaminergic receptors). It has to date beenshown to be safe and well tolerated, with clinical efficacycomparable to that of selective serotonin reuptake inhibitors(SSRIs).