This article is available to members only. Please enjoy the abstract for free. Subscribe for instant access to the full article.
This content is restricted to subscribers
Continue Reading...
Did you know members enjoy unlimited free PDF downloads as part of their subscription? Subscribe today for instant access to this article and our entire library in your preferred format. Alternatively, you can purchase the PDF of this article individually.
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
References (55)
Perälä J, Suvisaari J, Saarni SI, et al. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch Gen Psychiatry. 2007;64(1):19–28. PubMedCrossRef
Awad AG, Voruganti LN. The burden of schizophrenia on caregivers: a review. Pharmacoeconomics. 2008;26(2):149–162. PubMedCrossRef
Fekadu W, Mihiretu A, Craig TKJ, et al. Multidimensional impact of severe mental illness on family members: systematic review. BMJ Open. 2019;9(12):e032391. PubMedCrossRef
Cloutier M, Aigbogun MS, Guerin A, et al. The economic burden of schizophrenia in the United States in 2013. J Clin Psychiatry. 2016;77(6):764–771. PubMedCrossRef
Robinson D, Woerner MG, Alvir JM, et al. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry. 1999;56(3):241–247. PubMedCrossRef
Gitlin M, Nuechterlein K, Subotnik KL, et al. Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. Am J Psychiatry. 2001;158(11):1835–1842. PubMedCrossRef
Subotnik KL, Nuechterlein KH, Ventura J, et al. Risperidone nonadherence and return of positive symptoms in the early course of schizophrenia. Am J Psychiatry. 2011;168(3):286–292. PubMedCrossRef
Morken G, Widen JH, Grawe RW. Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia. BMC Psychiatry. 2008;8(1):32. PubMedCrossRef
Hill M, Crumlish N, Whitty P, et al. Nonadherence to medication four years after a first episode of psychosis and associated risk factors. Psychiatr Serv. 2010;61(2):189–192. PubMedCrossRef
Novick D, Haro JM, Suarez D, et al. Predictors and clinical consequences of non-adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res. 2010;176(2-3):109–113. PubMedCrossRef
Lindenmayer JP, Liu-Seifert H, Kulkarni PM, et al. Medication nonadherence and treatment outcome in patients with schizophrenia or schizoaffective disorder with suboptimal prior response. J Clin Psychiatry. 2009;70(7):990–996. PubMedCrossRef
Takeuchi H, Siu C, Remington G, et al. Does relapse contribute to treatment resistance? antipsychotic response in first- vs second-episode schizophrenia. Neuropsychopharmacology. 2019;44(6):1036–1042. PubMedCrossRef
Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first-episode psychosis. Early Interv Psychiatry. 2009;3(4):259–265. PubMedCrossRef
Marshall M, Lewis S, Lockwood A, et al. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry. 2005;62(9):975–983. PubMedCrossRef
Harrigan SM, McGorry PD, Krstev H. Does treatment delay in first-episode psychosis really matter? Psychol Med. 2003;33(1):97–110. PubMedCrossRef
Penttilä M, Jääskeläinen E, Hirvonen N, et al. Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Br J Psychiatry. 2014;205(2):88–94. PubMedCrossRef
Coldham EL, Addington J, Addington D. Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand. 2002;106(4):286–290. PubMedCrossRef
Tan C, Abdin E, Liang W, et al. Medication adherence in first-episode psychosis patients in Singapore. Early Interv Psychiatry. 2019;13(4):780–788. PubMedCrossRef
Raghavan V, Mohan G, Gopal S, et al. Medication adherence in first-episode psychosis and its association with psychopathology. Indian J Psychiatry. 2019;61(4):342–346. PubMedCrossRef
Kampman O, Laippala P, Väänänen J, et al. Indicators of medication compliance in first-episode psychosis. Psychiatry Res. 2002;110(1):39–48. PubMedCrossRef
Quach PL, Mors O, Christensen TO, et al. Predictors of poor adherence to medication among patients with first-episode schizophrenia-spectrum disorder. Early Interv Psychiatry. 2009;3(1):66–74. PubMedCrossRef
Steger KA, Cassidy C, Rabinovitch M, et al. Impact of symptom resolution on medication adherence in first episode psychosis. Psychiatry Res. 2012;196(1):45–51. PubMedCrossRef
Perkins DO, Johnson JL, Hamer RM, et al; HGDH Research Group. Predictors of antipsychotic medication adherence in patients recovering from a first psychotic episode. Schizophr Res. 2006;83(1):53–63. PubMedCrossRef
Lambert M, Conus P, Cotton S, et al. Prevalence, predictors, and consequences of long-term refusal of antipsychotic treatment in first-episode psychosis. J Clin Psychopharmacol. 2010;30(5):565–572. PubMedCrossRef
Kovasznay B, Fleischer J, Tanenberg-Karant M, et al. Substance use disorder and the early course of illness in schizophrenia and affective psychosis. Schizophr Bull. 1997;23(2):195–201. PubMedCrossRef
Mutsatsa SH, Joyce EM, Hutton SB, et al. Clinical correlates of early medication adherence: West London first episode schizophrenia study. Acta Psychiatr Scand. 2003;108(6):439–446. PubMedCrossRef
Leclerc E, Noto C, Bressan RA, et al. Determinants of adherence to treatment in first-episode psychosis: a comprehensive review. Br J Psychiatry. 2015;37(2):168–176. PubMedCrossRef
Shinn AK, Bolton KW, Karmacharya R, et al. McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis. Early Interv Psychiatry. 2017;11(1):83–90. PubMedCrossRef
Shinn AK, Cawkwell PB, Bolton K, et al. Return to college after a first episode of psychosis. Schizophr Bull Open. 2020;1(1):a041. PubMedCrossRef
Harris PA, Taylor R, Thielke R, et al. Research electronic data capture (REDCap)––a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–381. PubMedCrossRef
Valenstein M, Kavanagh J, Lee T, et al. Using a pharmacy-based intervention to improve antipsychotic adherence among patients with serious mental illness. Schizophr Bull. 2011;37(4):727–736. PubMedCrossRef
Karve S, Cleves MA, Helm M, et al. Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin. 2009;25(9):2303–2310. PubMedCrossRef
Caseiro O, Pérez-Iglesias R, Mata I, et al. Predicting relapse after a first episode of non-affective psychosis: a three-year follow-up study. J Psychiatr Res. 2012;46(8):1099–1105. PubMedCrossRef
Cassidy CM, Rabinovitch M, Schmitz N, et al. A comparison study of multiple measures of adherence to antipsychotic medication in first-episode psychosis. J Clin Psychopharmacol. 2010;30(1):64–67. PubMedCrossRef
Jónsdóttir H, Opjordsmoen S, Birkenaes AB, et al. Medication adherence in outpatients with severe mental disorders: relation between self-reports and serum level. J Clin Psychopharmacol. 2010;30(2):169–175. PubMedCrossRef
Cawkwell PB, Bolton KW, Karmacharya R, et al. Two-year diagnostic stability in a real-world sample of individuals with early psychosis. Early Interv Psychiatry. 2020;14(6):751–754. PubMedCrossRef
Perkins DO, Gu H, Weiden PJ, et al; Comparison of Atypicals in First Episode study group. Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study. J Clin Psychiatry. 2008;69(1):106–113. PubMedCrossRef
Opolka JL, Rascati KL, Brown CM, et al. Role of ethnicity in predicting antipsychotic medication adherence. Ann Pharmacother. 2003;37(5):625–630. PubMedCrossRef
Lacro JP, Dunn LB, Dolder CR, et al. Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: a comprehensive review of recent literature. J Clin Psychiatry. 2002;63(10):892–909. PubMedCrossRef
McQuaid EL, Landier W. Cultural issues in medication adherence: disparities and directions. J Gen Intern Med. 2018;33(2):200–206. PubMedCrossRef
Haskard Zolnierek KB, Dimatteo MR. Physician communication and patient adherence to treatment: a meta-analysis. Med Care. 2009;47(8):826–834. PubMedCrossRef
Freudenreich O. Psychotic Disorders: A Practical Guide. 2nd ed. Springer International Publishing; 2020.
Høyer G. On the justification for civil commitment. Acta Psychiatr Scand suppl. 2000;101(399):65–71. PubMedCrossRef
David AS. Insight and psychosis. Br J Psychiatry. 1990;156(6):798–808. PubMedCrossRef
Amador XF, Strauss DH, Yale SA, et al. Assessment of insight in psychosis. (see comments) Am J Psychiatry. 1993;150(6):873–879. PubMedCrossRef
Beck AT, Baruch E, Balter JM, et al. A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophr Res. 2004;68(2–3):319–329. PubMedCrossRef
Capdevielle D, Norton J, Aouizerate B, et al; FACE-SCZ Group. Comparison of three scales (BIS, SUMD and BCIS) for measuring insight dimensions and their evolution after one-year of follow-up: findings from the FACE-SZ Cohort. Psychiatry Res. 2021;303:114044. PubMedCrossRef
Droulout T, Liraud F, Verdoux H. Relationships between insight and medication adherence in subjects with psychosis [Influence de la conscience du trouble et de la perception subjective du traitement sur l’observance medicamenteuse dans les troubles psychotiques]. Encephale. 2003;29(5):430–437. PubMed
Novick D, Montgomery W, Treuer T, et al. Relationship of insight with medication adherence and the impact on outcomes in patients with schizophrenia and bipolar disorder: results from a 1-year European outpatient observational study. BMC Psychiatry. 2015;15(1):189. PubMedCrossRef
Lui SSY, Lam JPY, Lam JWS, et al. Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients. Asian J Psychiatr. 2021;60:102644. PubMedCrossRef
David AS. Insight and psychosis: the next 30 years. Br J Psychiatry. 2020;217(3):521–523. PubMedCrossRef
Pijnenborg GH, van Donkersgoed RJ, David AS, et al. Changes in insight during treatment for psychotic disorders: a meta-analysis. Schizophr Res. 2013;144(1-3):109–117. PubMedCrossRef
Swofford CD, Kasckow JW, Scheller-Gilkey G, et al. Substance use: a powerful predictor of relapse in schizophrenia. Schizophr Res. 1996;20(1-2):145–151. PubMedCrossRef
Hides L, Dawe S, Kavanagh DJ, et al. Psychotic symptom and cannabis relapse in recent-onset psychosis. prospective study. Br J Psychiatry. 2006;189(2):137–143. PubMedCrossRef