Manic and Psychotic Symptoms Following Risperidone Withdrawal in a Schizophrenic Patient

Sir: Risperidone, a serotonin-2/dopamine-2 (5HT₂/D₂) receptor antagonist, has been demonstrated to be effective in reducing both positive and negative symptoms of schizophrenia. Concerning its withdrawal-related symptoms, only akathisia and dyskinesia have been reported. In contrast, rapid discontinuation of clozapine, another atypical antipsychotic agent, could cause various symptoms including conscious disturbance, rebound psychosis, dyskinesia, motor restlessness, anxiety, insomnia, nausea, and diaphoresis.