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  1. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  2. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  3. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  4. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  5. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  6. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  7. Corresponding Author: Mu-Hong Chen, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Rd, Beitou District, Taipei 112, Taiwan ([email protected]).
  8. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  9. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  10. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
  11. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  12. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
  13. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  14. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  15. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  16. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  17. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  18. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  19. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  20. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  21. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  22. Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
  23. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
  24. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
  25. Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
  26. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
  1. Zheng Y, Molassiotis A, Tyrovolas S, et al. Epidemiological changes, demographic drivers, and global years of life lost from suicide over the period 1990–2019. Suicide Life Threat Behav. 2022;52(3):439–451. PubMed CrossRef
  2. Fu TST, Lee CS, Gunnell D, et al. Changing trends in the prevalence of common mental disorders in Taiwan: a 20-year repeated cross-sectional survey. Lancet. 2013;381(9862):235–241. PubMed CrossRef
  3. Price RB, Kissel N, Baumeister A, et al. International pooled patient-level meta analysis of ketamine infusion for depression: in search of clinical moderators. Mol Psychiatry. 2022;27(12):5096–5112. PubMed CrossRef
  4. Su TP, Chen MH, Li CT, et al. Dose-related effects of adjunctive ketamine in Taiwanese patients with treatment-resistant depression. Neuropsychopharmacology. 2017;42(13):2482–2492. PubMed CrossRef
  5. Su TP, Li CT, Lin WC, et al. A randomized, double-blind, midazolam-controlled trial of low-dose ketamine infusion in patients with treatment-resistant depression and prominent suicidal ideation. Int J Neuropsychopharmacol. 2023;26(5):331–339. PubMed CrossRef
  6. Beck AT, Brown G, Steer RA. Prediction of eventual suicide in psychiatric inpatients by clinical ratings of hopelessness. J Consult Clin Psychol. 1989;57(2):309–310. PubMed CrossRef
  7. Beck AT, Brown G, Berchick RJ, et al. Relationship between hopelessness and ultimate suicide: a replication with psychiatric outpatients. Am J Psychiatry. 1990;147(2):190–195. PubMed CrossRef
  8. Li Y, Kwok SYCL. A longitudinal network analysis of the interactions of risk and protective factors for suicidal potential in early adolescents. J Youth Adolesc. 2023;52(2):306–318. PubMed
  9. Ribeiro JD, Huang X, Fox KR, et al. Depression and hopelessness as risk factors for suicide ideation, attempts and death: meta-analysis of longitudinal studies. Br J Psychiatry. 2018;212(5):279–286. PubMed CrossRef
  10. Qiu T, Klonsky ED, Klein DN. Hopelessness predicts suicide ideation but not attempts: a 10-year longitudinal study. Suicide Life Threat Behav. 2017;47(6):718–722. PubMed CrossRef
  11. Ropaj E. Hope and suicidal ideation and behaviour. Curr Opin Psychol. 2023;49:101491. PubMed CrossRef
  12. Grunebaum MF, Galfalvy HC, Choo TH, et al. Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial. Am J Psychiatry. 2018;175(4):327–335. PubMed CrossRef
  13. Witte TK, Joiner TE Jr., Brown GK, et al. Factors of suicide ideation and their relation to clinical and other indicators in older adults. J Affect Disord. 2006;94(1–3):165–172. PubMed CrossRef
  14. DiazGranados N, Ibrahim LA, Brutsche NE, et al. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry. 2010;71(12):1605–1611. PubMed CrossRef
  15. Domany Y, Shelton RC, McCullumsmith CB. Ketamine for acute suicidal ideation. An emergency department intervention: a randomized, double-blind, placebo controlled, proof-of-concept trial. Depress Anxiety. 2020;37(3):224–233. PubMed CrossRef
  16. Osman A, Gutierrez PM, Kopper BA, et al. The positive and negative suicide ideation inventory: development and validation. Psychol Rep. 1998;82(3 Pt 1):783–793. PubMed CrossRef
  17. Evers AG, Murrough JW, Charney DS, et al. Ketamine as a prophylactic resilience enhancing agent. Front Psychiatry. 2022;13:833259. PubMed CrossRef
  18. Brachman RA, McGowan JC, Perusini JN, et al. Ketamine as a prophylactic against stress-induced depressive-like behavior. Biol Psychiatry. 2016;79(9):776–786. PubMed CrossRef
  19. Montgomery SA. Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients. Neuropharmacology. 1980;19(12):1185–1190. PubMed CrossRef
  20. Price RB, Nock MK, Charney DS, et al. Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry. 2009;66(5):522–526. PubMed CrossRef
  21. Kliem S, Lohmann A, Mößle T, et al. Psychometric properties and measurement invariance of the Beck hopelessness scale (BHS): results from a German representative population sample. BMC psychiatry. 2018;18(1):110. PubMed CrossRef
  22. Chen W, Yang T, Gao R, et al. The factor structure and psychometric properties of the Chinese version of the Positive and Negative Suicide Ideation Inventory (PANSI-C) in a non-clinical sample of Chinese adolescents. Ann Gen Psychiatry. 2021;20(1):47. PubMed CrossRef
  23. Sinniah A, Oei TPS, Chinna K, et al. Psychometric properties and validation of the positive and negative suicide ideation (PANSI) inventory in an outpatient clinical population in Malaysia. Front Psychol. 2015;6:1934. PubMed CrossRef
  24. Horwitz AG, Berona J, Czyz EK, et al. Positive and negative expectations of hopelessness as longitudinal predictors of depression, suicidal ideation, and suicidal behavior in high-risk adolescents. Suicide Life Threat Behav. 2017;47(2):168–176. PubMed CrossRef
  25. Lascelles K, Marzano L, Brand F, et al. Ketamine treatment for individuals with treatment-resistant depression: longitudinal qualitative interview study of patient experiences. BJPsych Open. 2020;7(1):e9. PubMed CrossRef
  26. Ballard ED, Farmer CA, Gerner J, et al. Prospective association of psychological pain and hopelessness with suicidal thoughts. J Affect Disord. 2022;308:243–248. PubMed CrossRef
  27. Papp M, Gruca P, Lason-Tyburkiewicz M, et al. Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression. Behav Pharmacol. 2017;28(1):1–8. PubMed CrossRef
  28. Li CT, Chen MH, Lin WC, et al. The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: a randomized controlled study. Hum Brain Mapp. 2016;37(3):1080–1090. PubMed CrossRef
  29. Chen MH, Li CT, Lin WC, et al. Persistent antidepressant effect of low-dose ketamine and activation in the supplementary motor area and anterior cingulate cortex in treatment-resistant depression: a randomized control study. J Affect Disord. 2018;225:709–714. PubMed CrossRef
  30. Wu J, Dong D, Jackson T, et al. The neural correlates of optimistic and depressive tendencies of self-evaluations and resting-state default mode network. Front Hum Neurosci. 2015;9:618. PubMed CrossRef
  31. Erthal F, Bastos A, Vilete L, et al. Unveiling the neural underpinnings of optimism: a systematic review. Cogn Affect Behav Neurosci. 2021;21(5):895–916. PubMed CrossRef
  32. Morris LS, Costi S, Tan A, et al. Ketamine normalizes subgenual cingulate cortex hyper-activity in depression. Neuropsychopharmacology. 2020;45(6):975–981. PubMed CrossRef
  33. McGhee LL, Maani CV, Garza TH, et al. The correlation between ketamine and posttraumatic stress disorder in burned service members. J Trauma. 2008;64(2 suppl):S195–S198. PubMed CrossRef
  34. McGhee LL, Maani CV, Garza TH, et al. The relationship of intravenous midazolam and posttraumatic stress disorder development in burned soldiers. J Trauma. 2009;66(4 suppl):S186–S190. PubMed CrossRef
  35. Du R, Han R, Niu K, et al. The multivariate effect of ketamine on PTSD: systematic review and meta-analysis. Front Psychiatry. 2022;13:813103. PubMed CrossRef
  36. Abbar M, Demattei C, El-Hage W, et al. Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial. BMJ. 2022;376:e067194. PubMed CrossRef
  37. Kwok SYCL, Shek DTL. Hopelessness, parent-adolescent communication, and suicidal ideation among Chinese adolescents in Hong Kong. Suicide Life Threat Behav. 2010;40(3):224–233. PubMed CrossRef
  38. Obayuwana AO, Collins JL, Carter AL, et al. Hope Index Scale: an instrument for the objective assessment of hope. J Natl Med Assoc. 1982;74:761–765. PubMed