Introduction. Pharmacologic Treatments of Major Depression: Are Two Mechanisms Really Better Than One?

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In the past 15 years, psychiatry has evolved rapidly, largely propelled by advances in the neurosciences and pharmacotherapy. As recently as the 1980s, the use of medications to treat depressive disorders was limited primarily to the most ill of patients. Today's antidepressants, however, treat a wide range of conditions with a spectrum of severity, and as such they have become one of the topselling classes of medications.' ‹' ‹