Initial Evidence of the Beneficial Effects of Glutamate-Modulating Agents in the Treatment of Self-Injurious Behavior Associated With Borderline Personality Disorder

Christopher Pittenger, MD, PhD; John H. Krystal, MD; Vladimir Coric, MD

J Clin Psychiatry 2005;66(11):1492-1493

Article Abstract

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Sir: Self-injurious behavior (SIB) in patients with borderlinepersonality disorder (BPD), especially cutting, represents aserious and often intractable clinical problem.¹ There are fewvalidated pharmacologic strategies for managing SIB.^1-3 Wedescribe our initial experience using glutamate-modulatingagents in 2 patients with BPD and prominent SIBs.’ ‹