Inability to Cry During SRI Treatment

Letter to the Editor

Sir: It has been our clinical experience that serotonin reuptake
inhibitors (SRIs) rapidly improve the symptom of excessive
or inappropriate crying in depressed patients. This is consistent
with reports in which SRIs improve pathologic crying in
stroke patients. We, however, report three cases in which patients
complained that they were unable to cry during SRI treatment.
We know of no previous reports of this SRI-induced adverse
effect.