This article is available to members only. Please enjoy the abstract for free. Subscribe for instant access to the full article.

This content is restricted to subscribers

Continue Reading...

Did you know members enjoy unlimited free PDF downloads as part of their subscription? Subscribe today for instant access to this article and our entire library in your preferred format. Alternatively, you can purchase the PDF of this article individually.

Subscribe Now

Already a member? Login

Purchase PDF for $40

Members enjoy free PDF downloads on all articles. Join today

  1. Toronto Centre for Liver Disease, University Health Network, Canada
  2. Corresponding Author: Erin Mandel, MPH, Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, 200 Elizabeth Street 9EB 240, Toronto, ON M5G 2C4 ([email protected]).
  3. VIRCAN Study Group, University Health Network, Toronto, Canada
  4. School of Nursing, York University, Toronto, Canada
  5. Toronto Centre for Liver Disease, University Health Network, Canada
  6. VIRCAN Study Group, University Health Network, Toronto, Canada
  7. Centre for Addiction and Mental Health, Toronto, Canada
  8. Centre for Addiction and Mental Health, Toronto, Canada
  9. VIRCAN Study Group, University Health Network, Toronto, Canada
  10. VIRCAN Study Group, University Health Network, Toronto, Canada
  11. VIRCAN Study Group, University Health Network, Toronto, Canada
  12. Toronto Centre for Liver Disease, University Health Network, Canada
  13. VIRCAN Study Group, University Health Network, Toronto, Canada
  14. Centre for Addiction and Mental Health, Toronto, Canada
  1. Kwong JC, Ratnasingham S, Campitelli MA, et al. The impact of infection on population health: results of the Ontario Burden of Infectious Diseases Study. PLoS One. 2012;7(9):e44103. PubMed CrossRef
  2. Popovic N, Williams A, Périnet S, et al. National hepatitis C estimates: Incidence, prevalence, undiagnosed proportion and treatment, Canada, 2019. Can Commun Dis Rep. 2022;48(11/12):540–549. CrossRef
  3. Hughes E, Bassi S, Gilbody S, et al. Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3(1):40–48. PubMed CrossRef
  4. Trager E, Khalili M, Masson CL, et al. Hepatitis C screening rate among underserved adults with serious mental illness receiving care in California community mental health centers. Am J Public Health. 2016;106(4):740–742. PubMed CrossRef
  5. Sylvestre DL, Loftis JM, Hauser P, et al. Co-occurring Hepatitis C, substance use, and psychiatric illness: treatment issues and developing integrated models of care. J Urban Health. 2004;81(4):719–734. PubMed CrossRef
  6. Schaefer M, Hinzpeter A, Mohmand A, et al. Hepatitis C treatment in “difficult-to-treat” psychiatric patients with pegylated interferon-alpha and ribavirin: response and psychiatric side effects. Hepatology. 2007;46(4):991–998. PubMed CrossRef
  7. Tang LS, Masur J, Sims Z, et al. Safe and effective sofosbuvir-based therapy in patients with mental health disease on hepatitis C virus treatment. World J Hepatol. 2016;8(31):1318–1326. PubMed CrossRef
  8. Mandel E, Underwood K, Masterman C, et al. Province to province variability in hepatitis C testing, care, and treatment across Canada. Can Liver J. Forthcoming.
  9. Miarons M, Sánchez-Ulayar A, Sempere G, et al. New direct-acting antivirals for hepatitis C treatment and neuropsychiatric symptoms in psychiatric risk groups. Eur J Hosp Pharm Sci Pract. 2019;26(3):135–139. PubMed CrossRef
  10. Hauser P, Kern S. Psychiatric and substance use disorders co-morbidities and hepatitis C: diagnostic and treatment implications. World J Hepatol. 2015;7(15):1921–1935. PubMed CrossRef
  11. Paisi M, Crombag N, Burns L, et al. Barriers and facilitators to hepatitis C screening and treatment for people with lived experience of homelessness: a mixed-methods systematic review. Health Expect. 2022;25(1):48–60. PubMed CrossRef
  12. Kattakuzhy S, Gross C, Emmanuel B, et al; ASCEND Providers. Expansion of treatment for hepatitis C virus infection by task shifting to community-based nonspecialist providers: a nonrandomized clinical trial. Ann Intern Med. 2017;167(5):311–318. PubMed CrossRef
  13. Cuadrado A, Llerena S, Cobo C, et al. Microenvironment eradication of hepatitis C: a novel treatment paradigm. Am J Gastroenterol. 2018;113(11):1639–1648. PubMed CrossRef
  14. Chhatwal J, Chen Q, Bethea ED, et al. The impact of direct-acting anti-virals on the hepatitis C care cascade: identifying progress and gaps towards hepatitis C elimination in the United States. Aliment Pharmacol Ther. 2019;50(1):66–74. PubMed CrossRef
  15. World Health Organization. Combating Hepatitis B and C to Reach Elimination by 2030: Advocacy Brief. May 2016. https://apps.who.int/iris/bitstream/handle/10665/206453/WHO_HIV_2016.04_eng.pdf?sequence=1&isAllowed=y
  16. Wade AJ, Doyle JS, Gane E, et al. Outcomes of treatment for hepatitis C in primary care, compared to hospital-based care: a randomized, controlled trial in people who inject drugs. Clin Infect Dis. 2020;70(9):1900–1906. PubMed CrossRef
  17. Roder C, Nguyen P, Harvey C, et al. Psychiatrists can treat hepatitis C. J Viral Hepat. 2021;28(12):1763–1764. PubMed CrossRef
  18. Aldridge RW, Story A, Hwang SW, et al. Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis. Lancet. 2018;391(10117):241–250. PubMed CrossRef
  19. Vallet-Pichard A, Mallet V, Nalpas B, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest. Hepatology. 2007;46(1):32–36. PubMed CrossRef
  20. Sterling RK, Lissen E, Clumeck N, et al; APRICOT Clinical Investigators. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317–1325. PubMed CrossRef
  21. McNeish D. Missing data methods for arbitrary missingness with small sample. J Appl Stat. 2015;44(1):24–39. CrossRef
  22. White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011;30(4):377–399. PubMed CrossRef
  23. Shah H, Bilodeau M, Burak KW, et al; Canadian Association for the Study of the Liver. The management of chronic hepatitis C: 2018 guideline update from the Canadian Association for the Study of the Liver. CMAJ. 2018;190(22):E677–E687. PubMed CrossRef
  24. Crismale JF, Ahmad J. Expanding treatment for hepatitis C in Canada. CMAJ. 2018;190(22):E667–E668. PubMed CrossRef
  25. Mandel E, Peci A, Cronin K, et al. The impact of the first, second and third waves of COVID-19 on hepatitis B and C testing in Ontario, Canada. J Viral Hepat. 2022;29(3):205–208. PubMed CrossRef
  26. Wolfson-Stofko B, Karkada J, Vanderhoff A, et al. The hepatitis C prevalence and treatment uptake at opioid agonist therapy clinics. Presented at INHSU 2021; October 13–15, 2021. Ontario, Canada.
  27. Biondi MJ, Hirode G, Capraru C, et al. Birth cohort hepatitis C antibody prevalence in real-world screening settings in Ontario. Can Liver J. 2022;5(3):362–371. PubMed CrossRef
  28. Schillie S, Wester C, Osborne M, et al. CDC recommendations for hepatitis C screening among adults — United States, 2020: recommendations and reports. MMWR Recomm Rep. 2020;69(2):1–17. PubMed
  29. Le E, Chee G, Kwan M, et al. Treating the hardest to treat: reframing the hospital admission as an opportunity to initiate hepatitis C treatment. Dig Dis Sci. 2022;67(4):1244–1251. PubMed CrossRef
  30. Valerio H, Alavi M, Law M, et al. Opportunities to enhance linkage to hepatitis C care among hospitalized people with recent drug dependence in New South Wales, Australia: a population-based linkage study. Clin Infect Dis. 2021;73(11):2037–2044. PubMed CrossRef
  31. Younossi Z, Park H, Henry L, et al. Extrahepatic manifestations of hepatitis C: a meta-analysis of prevalence, quality of life, and economic burden. Gastroenterology. 2016;150(7):1599–1608. PubMed CrossRef
  32. Yarlott L, Heald E, Forton D. Hepatitis C virus infection, and neurological and psychiatric disorders: a review. J Adv Res. 2017;8(2):139–148. PubMed CrossRef
  33. Hilsabeck RC, Hassanein TI, Carlson MD, et al. Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C. J Int Neuropsychol Soc. 2003;9(6):847–854. PubMed CrossRef
  34. Cooper CL, Galanakis C, Donelle J, et al. HCV-infected individuals have higher prevalence of comorbidity and multimorbidity: a retrospective cohort study. BMC Infect Dis. 2019;19(1):712. PubMed CrossRef