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  1. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  2. Division of Psychiatry, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  3. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  4. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  5. Graduate Institute of Statistics National Central University, Taoyuan, Taiwan
  6. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  7. Division of Psychiatry, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  8. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  9. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  10. Division of Psychiatry, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  11. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  12. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  13. Division of Psychiatry, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  14. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  15. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  16. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  17. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  18. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  19. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  20. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  21. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
  22. Department of Family Medicine, Taipei Veterans General Hospital, Taiwan
  23. Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu, Taiwan
  24. Department of Psychiatry, Taipei Veterans General Hospital, Taiwan
  25. Institute of Brain Science, School of Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan
  26. Corresponding Author: Mu-Hong Chen, MD, PhD, Department of Psychiatry, Taipei Veterans General Hospital, No 201, Sec 2, Shih-Pai Road, Beitou District, Taipei, 112, Taiwan ([email protected]).
  1. Laursen TM, Plana-Ripoll O, Andersen PK, et al. Cause-specific life years lost among persons diagnosed with schizophrenia: is it getting better or worse? Schizophr Res. 2019;206:284–290. PubMed CrossRef
  2. Tanskanen A, Tiihonen J, Taipale H. Mortality in schizophrenia: 30-year nationwide follow-up study. Acta Psychiatr Scand. 2018;138(6):492–499. PubMed CrossRef
  3. Hjorthøj C, Stürup AE, McGrath JJ, et al. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry. 2017;4(4):295–301. PubMed CrossRef
  4. Crump C, Winkleby MA, Sundquist K, et al. Comorbidities and mortality in persons with schizophrenia: a Swedish national cohort study. Am J Psychiatry. 2013;170(3):324–333. PubMed CrossRef
  5. Høye A, Jacobsen BK, Hansen V. Increasing mortality in schizophrenia: are women at particular risk? a follow-up of 1111 patients admitted during 1980–2006 in Northern Norway. Schizophr Res. 2011;132(2-3):228–232. PubMed CrossRef
  6. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64(10):1123–1131. PubMed CrossRef
  7. Chen WJ, Huang YJ, Yeh LL, et al. Excess mortality of psychiatric inpatients in Taiwan. Psychiatry Res. 1996;62(3):239–250. PubMed CrossRef
  8. Pan YJ, Yeh LL, Chan HY, et al. Excess mortality and shortened life expectancy in people with major mental illnesses in Taiwan. Epidemiol Psychiatr Sci. 2020;29:e156. PubMed CrossRef
  9. Walker ER, McGee RE, Druss BG. Mortality in mental disorders and global disease burden implications: a systematic review and meta-analysis. JAMA Psychiatry. 2015;72(4):334–341. PubMed CrossRef
  10. Dickerson F, Origoni A, Schroeder J, et al. Mortality in schizophrenia and bipolar disorder: clinical and serological predictors. Schizophr Res. 2016;170(1):177–183. PubMed CrossRef
  11. Laursen TM, Nordentoft M, Mortensen PB. Excess early mortality in schizophrenia. Annu Rev Clin Psychol. 2014;10(1):425–448. PubMed CrossRef
  12. Dipasquale S, Pariante CM, Dazzan P, et al. The dietary pattern of patients with schizophrenia: a systematic review. J Psychiatr Res. 2013;47(2):197–207. PubMed CrossRef
  13. Fleury MJ, Grenier G, Bamvita JM, et al. Professional service utilisation among patients with severe mental disorders. BMC Health Serv Res. 2010;10(1):141. PubMed CrossRef
  14. Cradock-O’Leary J, Young AS, Yano EM, et al. Use of general medical services by VA patients with psychiatric disorders. Psychiatr Serv. 2002;53(7):874–878. PubMed CrossRef
  15. Huang MH, Chen MH, Huang KL, et al. Increased risk of type 2 diabetes among the siblings of patients with schizophrenia. CNS Spectr. 2019;24(4):453–459. PubMed CrossRef
  16. Ringen PA, Engh JA, Birkenaes AB, et al. Increased mortality in schizophrenia due to cardiovascular disease: a non-systematic review of epidemiology, possible causes, and interventions. Front Psychiatry. 2014;5:137. PubMed CrossRef
  17. Bai YM, Su TP, Chen MH, et al. Risk of developing diabetes mellitus and hyperlipidemia among patients with bipolar disorder, major depressive disorder, and schizophrenia: a 10-year nationwide population-based prospective cohort study. J Affect Disord. 2013;150(1):57–62. PubMed CrossRef
  18. Harris LW, Guest PC, Wayland MT, et al. Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies. Psychoneuroendocrinology. 2013;38(6):752–766. PubMed CrossRef
  19. Nielsen RE, Uggerby AS, Jensen SO, et al. Increasing mortality gap for patients diagnosed with schizophrenia over the last three decades: a Danish nationwide study from 1980 to 2010. Schizophr Res. 2013;146(1-3):22–27. PubMed CrossRef
  20. Dickerson F, Origoni A, Rowe K, et al. Risk factors for natural cause mortality in a cohort of 1494 persons with serious mental illness. Psychiatry Res. 2021;298:113755. PubMed CrossRef
  21. Berardi D, Stivanello E, Chierzi F, et al. Mortality in mental health patients of the Emilia-Romagna region of Italy: a registry-based study. Psychiatry Res. 2021;296:113702. PubMed CrossRef
  22. Das-Munshi J, Chang CK, Dutta R, et al. Ethnicity and excess mortality in severe mental illness: a cohort study. Lancet Psychiatry. 2017;4(5):389–399. PubMed CrossRef
  23. Brown S, Kim M, Mitchell C, et al. Twenty-five year mortality of a community cohort with schizophrenia. Br J Psychiatry. 2010;196(2):116–121. PubMed CrossRef
  24. Erlangsen A, Andersen PK, Toender A, et al. Cause-specific life-years lost in people with mental disorders: a nationwide, register-based cohort study. Lancet Psychiatry. 2017;4(12):937–945. PubMed CrossRef
  25. Olfson M, Gerhard T, Huang C, et al. Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry. 2015;72(12):1172–1181. PubMed CrossRef
  26. Pelton M, Ciarletta M, Wisnousky H, et al. Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a systematic review and meta-analysis. Gen Psychiatr. 2021;34(2):e100247. PubMed CrossRef
  27. Wang CC, Shao CH, Li HJ, et al. Profiles and persistence of initial antiretroviral therapy among HIV infected patients in Taiwan: a nationwide population-based cross-sectional study from 2011 to 2017. J Microbiol Immunol Infect. 2022;55(5):838–844. PubMed CrossRef
  28. de los Rios P, Okoli C, Punekar Y, et al. Prevalence, determinants, and impact of suboptimal adherence to HIV medication in 25 countries. Prev Med. 2020;139:106182. PubMed CrossRef
  29. Lee CY, Jen IA, Lan YC, et al. AIDS incidence trends at presentation and during follow-up among HIV-at-risk populations: a 15-year nationwide cohort study in Taiwan. BMC Public Health. 2018;18(1):589. PubMed CrossRef
  30. Closson K, McLinden T, Patterson TL, et al; Comparative Outcomes And Service Utilization Trends (COAST) Study. HIV, schizophrenia, and all-cause mortality: a population-based cohort study of individuals accessing universal medical care from 1998 to 2012 in British Columbia, Canada. Schizophr Res. 2019;209:198–205. PubMed CrossRef
  31. Quan H, Sundararajan V, Halfon P, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care. 2005;43(11):1130–1139. PubMed CrossRef
  32. Shinozaki T, Mansournia MA, Matsuyama Y. On hazard ratio estimators by proportional hazards models in matched-pair cohort studies: emerging themes in epidemiology. 2017;14(1):6.
  33. Correll CU, Solmi M, Croatto G, et al. Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors. World Psychiatry. 2022;21(2):248–271. PubMed CrossRef
  34. Haas AD, Ruffieux Y, van den Heuvel LL, et al; IeDEA Southern Africa collaboration. Excess mortality associated with mental illness in people living with HIV in Cape Town, South Africa: a cohort study using linked electronic health records. Lancet Glob Health. 2020;8(10):e1326–e1334. PubMed CrossRef
  35. GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022;9(2):137–150. PubMed CrossRef
  36. Carlborg A, Winnerbäck K, Jönsson EG, et al. Suicide in schizophrenia. Expert Rev Neurother. 2010;10(7):1153–1164. PubMed CrossRef
  37. Sher L, Kahn RS. Suicide in schizophrenia: an educational overview. Medicina (Kaunas). 2019;55(7):361. PubMed
  38. Thara R, Kamath S. Women and schizophrenia. Indian J Psychiatry. 2015;57(suppl 2):S246–S251. PubMed CrossRef
  39. Laursen TM, Munk-Olsen T, Gasse C. Chronic somatic comorbidity and excess mortality due to natural causes in persons with schizophrenia or bipolar affective disorder. PLoS One. 2011;6(9):e24597. PubMed CrossRef
  40. Sun D, Li L, Zhang X, et al. Causes of sudden unexpected death in schizophrenia patients: a forensic autopsy population study. Am J Forensic Med Pathol. 2019;40(4):312–317. PubMed CrossRef
  41. Mirza RA, Eick-Cost A, Otto JL. The risk of mental health disorders among US military personnel infected with human immunodeficiency virus, active component, US Armed Forces, 2000–2011. MSMR. 2012;19(5):10–13. PubMed
  42. Helleberg M, Pedersen MG, Pedersen CB, et al. Associations between HIV and schizophrenia and their effect on HIV treatment outcomes: a nationwide population-based cohort study in Denmark. Lancet HIV. 2015;2(8):e344–e350. PubMed CrossRef
  43. Wang LY, Chen SF, Chiang JH, et al. Autoimmune diseases are associated with an increased risk of schizophrenia: a nationwide population-based cohort study. Schizophr Res. 2018;202:297–302. PubMed CrossRef
  44. Benros ME, Pedersen MG, Rasmussen H, et al. A nationwide study on the risk of autoimmune diseases in individuals with a personal or a family history of schizophrenia and related psychosis. Am J Psychiatry. 2014;171(2):218–226. PubMed CrossRef
  45. Garen T, Lerang K, Hoffmann-Vold AM, et al. Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides. Rheumatology (Oxford). 2019;58(2):313–320. PubMed CrossRef
  46. Parperis K, Kyriakou A, Voskarides K, et al. Suicidal behavior in patients with systematic lupus erythematosus: systematic literature review and genetic linkage disequilibrium analysis. Semin Arthritis Rheum. 2022;54:151997. PubMed CrossRef
  47. Crump C, Sundquist K, Winkleby MA, et al. Mental disorders and risk of accidental death. Br J Psychiatry. 2013;203(4):297–302. PubMed CrossRef
  48. Hellemose LAA, Laursen TM, Larsen JT, et al. Accidental deaths among persons with schizophrenia: a nationwide population-based cohort study. Schizophr Res. 2018;199:149–153. PubMed CrossRef
  49. Bohnert AS, Ilgen MA, Ignacio RV, et al. Risk of death from accidental overdose associated with psychiatric and substance use disorders. Am J Psychiatry. 2012;169(1):64–70. PubMed CrossRef