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  1. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  2. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  3. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  4. Corresponding author: Theresa Wimberley, PhD, The National Centre for Register-based Research, Aarhus BSS, Aarhus University, Fuglesangs Allé 26, DK-8210 Aarhus V ([email protected]).
  5. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  6. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  7. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  8. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  9. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  10. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  11. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  12. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  13. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  14. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  15. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  16. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  17. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  18. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  19. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  20. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  21. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  22. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  23. Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
  24. Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
  25. School of Psychology, Cardiff University, Cardiff, United Kingdom
  26. Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, United Kingdom
  27. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  28. Department of Economics and Business Economics, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark
  29. Department of Economics and Business Economics, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark
  30. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  31. Department of Biomedicine and Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark
  32. Center for Genomics and Personalized Medicine, Central Region Denmark and Aarhus University, Aarhus, Denmark
  33. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  34. CORE, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark
  35. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  36. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  37. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  38. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen and Aarhus, Denmark
  39. National Centre for Register-based Research (NCRR), Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  40. Centre for Integrated Register-based Research, Aarhus University (CIRRAU), Aarhus, Denmark
  1. Sonuga-Barke EJ, Daley D, Thompson M, et al. Preschool ADHD: exploring uncertainties in diagnostic validity and utility, and treatment efficacy and safety. Expert Rev Neurother. 2003;3(4):465–476. PubMed CrossRef
  2. Dal Santo JA, Goodman RM, Glik D, et al. Childhood unintentional injuries: factors predicting injury risk among preschoolers. J Pediatr Psychol. 2004;29(4):273–283. PubMed CrossRef
  3. Bourguet CC, McArtor RE. Unintentional injuries: risk factors in preschool children. Am J Dis Child. 1989;143(5):556–559. PubMed CrossRef
  4. Ribeiro MGC, Paula ABR, Bezerra MAR, et al. Social determinants of health associated with childhood accidents at home: an integrative review. Rev Bras Enferm. 2019;72(1):265–276. PubMed CrossRef
  5. Seidman LJ, Biederman J, Monuteaux MC, et al. Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years? Dev Neuropsychol. 2005;27(1):79–105. PubMed CrossRef
  6. Garzon DL. Contributing factors to preschool unintentional injury. J Pediatr Nurs. 2005;20(6):441–447. PubMed CrossRef
  7. Klein D. Some applications of delinquency theory to childhood accidents. Pediatrics. 1969;44(5):805–810. PubMed
  8. Matheny AP Jr. Injuries among toddlers: contributions from child, mother, and family. J Pediatr Psychol. 1986;11(2):163–176. PubMed CrossRef
  9. Langley J, McGee R, Silva P, et al. Child behavior and accidents. J Pediatr Psychol. 1983;8(2):181–189. PubMed CrossRef
  10. Speltz ML, Gonzales N, Sulzbacher S, et al. Assessment of injury risk in young children: a preliminary study of the Injury Behavior Checklist. J Pediatr Psychol. 1990;15(3):373–383. PubMed CrossRef
  11. Piazza-Waggoner C, Dotson C, Adams CD, et al. Preinjury behavioral and emotional problems among pediatric burn patients. J Burn Care Rehabil. 2005;26(4):371–378, discussion 369–370. PubMed CrossRef
  12. Dalsgaard S, Nielsen HS, Simonsen M. Consequences of ADHD medication use for children’s outcomes. J Health Econ. 2014;37:137–151. PubMed CrossRef
  13. Dalsgaard S, Leckman JF, Mortensen PB, et al. Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study. Lancet Psychiatry. 2015;2(8):702–709. PubMed CrossRef
  14. Lindemann C, Langner I, Banaschewski T, et al. The risk of hospitalizations with injury diagnoses in a matched cohort of children and adolescents with and without attention deficit/hyperactivity disorder in Germany: a database study. Front Pediatr. 2017;5:220. PubMed CrossRef
  15. Ruiz-Goikoetxea M, Cortese S, Aznarez-Sanado M, et al. Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2018;84:63–71. PubMed CrossRef
  16. Adeyemo BO, Biederman J, Zafonte R, et al. Mild traumatic brain injury and ADHD: a systematic review of the literature and meta-analysis. J Atten Disord. 2014;18(7):576–584. PubMed CrossRef
  17. Chang HK, Hsu JW, Wu JC, et al. Traumatic brain injury in early childhood and risk of attention-deficit/hyperactivity disorder and autism spectrum disorder: a nationwide longitudinal study. J Clin Psychiatry. 2018;79(6):17m11857. PubMed CrossRef
  18. Stojanovski S, Felsky D, Viviano JD, et al. Polygenic risk and neural substrates of attention-deficit/hyperactivity disorder symptoms in youths with a history of mild traumatic brain injury. Biol Psychiatry. 2019;85(5):408–416. PubMed CrossRef
  19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th Edition. American Psychiatric Publishing; 2013.
  20. Faraone SV, Larsson H. Genetics of attention deficit hyperactivity disorder. Mol Psychiatry. 2019;24(4):562–575. PubMed CrossRef
  21. Stergiakouli E, Martin J, Hamshere ML, et al. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. J Am Acad Child Adolesc Psychiatry. 2015;54(4):322–327. PubMed CrossRef
  22. Riglin L, Collishaw S, Thapar AK, et al. Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population. JAMA Psychiatry. 2016;73(12):1285–1292. PubMed CrossRef
  23. Martin J, Hamshere ML, Stergiakouli E, et al. Genetic risk for attention-deficit/hyperactivity disorder contributes to neurodevelopmental traits in the general population. Biol Psychiatry. 2014;76(8):664–671. PubMed CrossRef
  24. Demontis D, Walters RK, Martin J, et al; ADHD Working Group of the Psychiatric Genomics Consortium (PGC); Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium; 23andMe Research Team. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nat Genet. 2019;51(1):63–75. PubMed CrossRef
  25. Lyngsøe BK, Munk-Olsen T, Vestergaard CH, et al. Maternal depression and childhood injury risk: a population-based cohort study in Denmark. Brain Behav. 2021;11(3):e02029. PubMed
  26. Ordoñana JR, Caspi A, Moffitt TE. Unintentional injuries in a twin study of preschool children: environmental, not genetic, risk factors. J Pediatr Psychol. 2008;33(2):185–194. PubMed CrossRef
  27. Salminen S, Vuoksimaa E, Rose RJ, et al. Age, sex, and genetic and environmental effects on unintentional injuries in young and adult twins. Twin Res Hum Genet. 2018;21(6):502–506. PubMed CrossRef
  28. Acar E, Dursun OB, Esin IS, et al. Unintentional injuries in preschool age children: is there a correlation with parenting style and parental attention deficit and hyperactivity symptoms. Medicine (Baltimore). 2015;94(32):e1378. PubMed CrossRef
  29. Pedersen CB, Gøtzsche H, Møller JØ, et al. The Danish Civil Registration System: a cohort of eight million persons. Dan Med Bull. 2006;53(4):441–449. PubMed
  30. Schmidt M, Schmidt SA, Sandegaard JL, et al. The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol. 2015;7:449–490. PubMed CrossRef
  31. Mors O, Perto GP, Mortensen PB. The Danish Psychiatric Central Research Register. Scand J Public Health. 2011;39(suppl):54–57. PubMed CrossRef
  32. World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. World Health Organization; 1992.
  33. Pedersen CB, Bybjerg-Grauholm J, Pedersen MG, et al. The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders. Mol Psychiatry. 2018;23(1):6–14. PubMed CrossRef
  34. Privé F, Luu K, Blum MGB, et al. Efficient toolkit implementing best practices for principal component analysis of population genetic data. Bioinformatics. 2020;36(16):4449–4457. PubMed CrossRef
  35. Loh PR, Bhatia G, Gusev A, et al; Schizophrenia Working Group of Psychiatric Genomics Consortium. Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis. Nat Genet. 2015;47(12):1385–1392. PubMed CrossRef
  36. Debost JC, Larsen JT, Munk-Olsen T, et al. Childhood infections and schizophrenia: the impact of parental SES and mental illness, and childhood adversities. Brain Behav Immun. 2019;81:341–347. PubMed CrossRef
  37. Vilhjálmsson BJ, Yang J, Finucane HK, et al; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) study. Modeling linkage disequilibrium increases accuracy of polygenic risk scores. Am J Hum Genet. 2015;97(4):576–592. PubMed CrossRef
  38. Loh PR, Tucker G, Bulik-Sullivan BK, et al. Efficient Bayesian mixed-model analysis increases association power in large cohorts. Nat Genet. 2015;47(3):284–290. PubMed CrossRef
  39. Albiñana C, Grove J, McGrath JJ, et al. Leveraging both individual-level genetic data and GWAS summary statistics increases polygenic prediction. Am J Hum Genet. 2021;108(6):1001–1011. PubMed CrossRef
  40. Borgan O, Langholz B, Samuelsen SO, et al. Exposure stratified case-cohort designs. Lifetime Data Anal. 2000;6(1):39–58. PubMed CrossRef
  41. Lee SH, Goddard ME, Wray NR, et al. A better coefficient of determination for genetic profile analysis. Genet Epidemiol. 2012;36(3):214–224. PubMed CrossRef
  42. Stata Statistical Software: Release 14. StataCorp; 2016.
  43. R Development Core Team. R: A Language and Environment for Statistical Programming. R Foundation for Statistical Consulting; 2010.
  44. Mortensen PB. Response to “Ethical concerns regarding Danish genetic research.” Mol Psychiatry. 2019;24(11):1574–1575. PubMed CrossRef
  45. Nørgaard-Pedersen B, Hougaard DM. Storage policies and use of the Danish Newborn Screening Biobank. J Inherit Metab Dis. 2007;30(4):530–536. PubMed CrossRef
  46. Nikolas MA, Elmore AL, Franzen L, et al. Risky bicycling behavior among youth with and without attention-deficit hyperactivity disorder. J Child Psychol Psychiatry. 2016;57(2):141–148. PubMed CrossRef
  47. Chang Z, Lichtenstein P, D’Onofrio BM, et al. Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study. JAMA Psychiatry. 2014;71(3):319–325. PubMed CrossRef
  48. Dalsgaard S, Østergaard SD, Leckman JF, et al. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet. 2015;385(9983):2190–2196. PubMed CrossRef
  49. Sun S, Kuja-Halkola R, Faraone SV, et al. Association of psychiatric comorbidity with the risk of premature death among children and adults with attention-deficit/hyperactivity disorder. JAMA Psychiatry. 2019;76(11):1141–1149. PubMed CrossRef
  50. Anttila V, Bulik-Sullivan B, Finucane HK, et al; Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395):eaap8757. PubMed
  51. Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell. 2019;179(7):1469–1482.e11. PubMed CrossRef
  52. Nevriana A, Pierce M, Dalman C, et al. Association between maternal and paternal mental illness and risk of injuries in children and adolescents: nationwide register based cohort study in Sweden. BMJ. 2020;369:m853. PubMed CrossRef
  53. McCoy BM, Rickert ME, Class QA, et al. Mediators of the association between parental severe mental illness and offspring neurodevelopmental problems. Ann Epidemiol. 2014;24(9):629–634.e1. PubMed CrossRef
  54. Sideri S, Marcenes W, Stansfeld SA, et al. Family environment and traumatic dental injuries in adolescents. Dent Traumatol. 2018;34(6):438–444. PubMed CrossRef
  55. Keilow M, Wu C, Obel C. Cumulative social disadvantage and risk of attention deficit hyperactivity disorder: results from a nationwide cohort study. SSM Popul Health. 2020;10:100548. PubMed CrossRef
  56. Østergaard SD, Dalsgaard S, Faraone SV, et al. Teenage parenthood and birth rates for individuals with and without attention-deficit/hyperactivity disorder: a nationwide cohort study. J Am Acad Child Adolesc Psychiatry. 2017;56(7):578–584.e3. PubMed CrossRef
  57. Harold GT, Leve LD, Barrett D, et al. Biological and rearing mother influences on child ADHD symptoms: revisiting the developmental interface between nature and nurture. J Child Psychol Psychiatry. 2013;54(10):1038–1046. PubMed CrossRef
  58. Stern A, Agnew-Blais J, Danese A, et al. Associations between abuse/neglect and ADHD from childhood to young adulthood: a prospective nationally-representative twin study. Child Abuse Negl. 2018;81:274–285. PubMed CrossRef
  59. Østergaard SD, Trabjerg BB, Als TD, et al. Polygenic risk score, psychosocial environment and the risk of attention-deficit/hyperactivity disorder. Transl Psychiatry. 2020;10(1):335. PubMed CrossRef
  60. Greenwood M, Woods HM. The Incidence of Industrial Accidents Upon Individuals, With Special Reference to Multiple Accidents. Her Majesty’s Stationery Office. Industrial Fatigue Research Board; 1919.
  61. Farmer E, Chambers EG. A Psychological Study of Individual Differences in Accident Rates. H. M. Stationery Office; 1926.
  62. Marbe K. Praktische Psychologie der Unfälle und Betriebsschäden. Oldenbourg; 1926.
  63. Newbold EM. A Contribution to the Study of the Human Factor in the Causation of Accidents. H.M.S.O.; 1926.
  64. Bakwin RM, Bakwin H. Accident proneness. J Pediatr. 1948;32(6):749–752. PubMed CrossRef
  65. Dalsgaard-Nielsen T, Dirksen H. Head injury and accident-proneness (somato-psychic causes of such injuries). Acta Psychiatr Neurol Scand. 1954;29(1):28–30. PubMed CrossRef
  66. Partington MW. The importance of accident-proneness in the aetiology of head injuries in childhood. Arch Dis Child. 1960;35(181):215–223. PubMed CrossRef
  67. Dunbar F. Psychosomatic Diagnosis. Paul B. Hoeber, Inc.; 1943:172–247.
  68. Froggatt P, Smiley JA. The concept of accident proneness: a review. Br J Ind Med. 1964;21(1):1–12. PubMed CrossRef
  69. McKenna FP. Accident proneness: a conceptual analysis. Accid Anal Prev. 1983;15(1):65–71. CrossRef
  70. Sundhedsstyrrelsen [Danish Health Authority], National Klinisk Retningslinje for Udredning og Behandling af ADHD Hos Børn og Unge [National Clinical Guideline for Assessment and Treatment of ADHD in Children and Adolescents]. 2018; v3.1. December 2018. https://www.sst.dk/-/media/Udgivelser/2018/National-Klinisk-Retningslinje-Udredning-og-behandling-af-ADHD-hos-boern-og-unge
  71. Mohr-Jensen C, Vinkel Koch S, Briciet Lauritsen M, et al. The validity and reliability of the diagnosis of hyperkinetic disorders in the Danish Psychiatric Central Research Registry. Eur Psychiatry. 2016;35:16–24. PubMed CrossRef
  72. Weissbrod O, Flint J, Rosset S. Estimating SNP-based heritability and genetic correlation in case-control studies directly and with summary statistics. Am J Hum Genet. 2018;103(1):89–99. PubMed CrossRef