Dosing Differences Between Valproic Acid Concentrate and Divalproex Sodium: A Case Report

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Sir: Valproic acid concentrate is an immediate-release preparation of valproic acid with rapid absorption following oral administration.¹ Divalproex sodium tablets are a delayedrelease formulation comprising valproate sodium and valproic acid in a 1:1 molar relationship.² Equivalent oral doses of divalproex sodium tablets and valproic acid concentrate deliver equivalent quantities of valproate ion systemically.