Divalproex Versus Olanzapine in Mania

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Sir: The article by Zajecka et al.¹on the efficacy and safetyof divalproex sodium versus olanzapine in the treatment ofbipolar disorder is interesting, but unfortunately it does notseem to truly support the authors’ conclusions.The first problem is sample size. According to previous experience with divalproex²and olanzapine,³this study was notclearly powered to show superiority of either drug over theother and it is unclear whether this trial was designed to proveeither superiority or noninferiority.’ ‹’ ‹