Multiple sclerosis (MS) is a devastating disease causing weakness, fatigue, cognitive problems, and other disabilities. Relapses cause significant functional impairment and decreased quality of life for patients with MS, and relapses are typically treated with short-term corticosteroids. Long-term treatment for relapsing MS consists of several types of disease-modifying therapies, most of which are administered by either IV or injection. While these therapies are effective, newer oral agents are now available. Although more long-term data are needed, oral agents may be more convenient and tolerable than injections or IVs and should be presented to patients as a potential therapy option.