Cognitive Effects of Electroconvulsive Therapy in Schizophrenia: A Systematic Review

References (72)

1. Dickinson D, Harvey PD. Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem. Schizophr Bull. 2009;35(2):403–414. PubMed CrossRef
2. Bowie CR, Harvey PD. Cognitive deficits and functional outcome in schizophrenia. Neuropsychiatr Dis Treat. 2006;2(4):531–536. PubMed CrossRef
3. Heaton RK, Gladsjo JA, Palmer BW, et al. Stability and course of neuropsychological deficits in schizophrenia. Arch Gen Psychiatry. 2001;58(1):24–32. PubMed CrossRef
4. Green MF, Kern RS, Braff DL, et al. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”. Schizophr Bull. 2000;26(1):119–136. PubMed CrossRef
5. Rajji TK, Miranda D, Mulsant BH. Cognition, function, and disability in patients with schizophrenia: a review of longitudinal studies. Can J Psychiatry. 2014;59(1):13–17. PubMed CrossRef
6. American Psychiatric Association. The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia. 3rd ed. American Psychiatric Association Publishing; 2020.
7. Remington G, Addington D, Honer W, et al. Guidelines for the pharmacotherapy of schizophrenia in adults. Can J Psychiatry. 2017;62(9):604–616. PubMed CrossRef
8. Keefe RSE, Bilder RM, Davis SM, et al. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial. Arch Gen Psychiatry. 2007;64(6):633–647. PubMed CrossRef
9. MacKenzie NE, Kowalchuk C, Agarwal SM, et al. Antipsychotics, metabolic adverse effects, and cognitive function in schizophrenia. Front Psychiatry. 2018;9:622. PubMed CrossRef
10. Siskind D, Orr S, Sinha S, et al. Rates of treatment-resistant schizophrenia from first-episode cohorts: systematic review and meta-analysis. Br J Psychiatry. 2022;220(3):115–120. PubMed CrossRef
11. Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382(9896):951–962. PubMed CrossRef
12. Siskind D, Siskind V, Kisely S. Clozapine response rates among people with treatment-resistant schizophrenia: data from a systematic review and meta analysis. Can J Psychiatry. 2017;62(11):772–777. PubMed CrossRef
13. Kane JM, Agid O, Baldwin ML, et al. Clinical guidance on the identification and management of treatment-resistant schizophrenia. J Clin Psychiatry. 2019;80(2):18com12123. PubMed CrossRef
14. Howes OD, McCutcheon R, Agid O, et al. Treatment-resistant schizophrenia: treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology. Am J Psychiatry. 2017;174(3):216–229. PubMed CrossRef
15. Lally J, Tully J, Robertson D, et al. Augmentation of clozapine with electroconvulsive therapy in treatment resistant schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2016;171(1–3):215–224. PubMed CrossRef
16. Sanghani SN, Petrides G, Kellner CH. Electroconvulsive therapy (ECT) in schizophrenia: a review of recent literature. Curr Opin Psychiatry. 2018;31(3):213–222. PubMed CrossRef
17. Yeh TC, Correll CU, Yang FC, et al. Pharmacological and nonpharmacological augmentation treatments for clozapine-resistant schizophrenia: a systematic review and network meta-analysis with normalized entropy assessment. Asian J Psychiatr. 2023;79:103375. PubMed CrossRef
18. Baldinger P, Lotan A, Frey R, et al. Neurotransmitters and electroconvulsive therapy. J ECT. 2014;30(2):116–121. PubMed CrossRef
19. Lyden H, Espinoza RT, Pirnia T, et al. Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression. Transl Psychiatry. 2014;4(4):e380. PubMed CrossRef
20. Bouckaert F, Sienaert P, Obbels J, et al. ECT: its brain enabling effects A review of electroconvulsive therapy–induced structural brain plasticity. J ECT. 2014;30(2):143–151. PubMed CrossRef
21. Jiang Y, Duan M, He H, et al. Structural and functional MRI brain changes in patients with schizophrenia following electroconvulsive therapy: a systematic review. Curr Neuropharmacol. 2022;20(6):1241–1252. PubMed CrossRef
22. Moon S-Y, Kim M, Lho SK, et al. Systematic review of the neural effect of electroconvulsive therapy in patients with schizophrenia: Hippocampus and insula as the key regions of Modulation. Psychiatry Investig. 2021;18(6):486–499. PubMed CrossRef
23. Fink M. Meduna and the origins of convulsive therapy. Am J Psychiatry. 1984;141(9):1034–1041. PubMed CrossRef
24. Leiknes KA, Jarosh-von Schweder L, Høie B. Contemporary use and practice of electroconvulsive therapy worldwide. Brain Behav. 2012;2(3):283–344. PubMed CrossRef
25. American Psychiatric Association. The Practice of ECT: Recommendations for Treatment, Training and Privileging. 2nd ed. American Psychiatric Press; 2001.
26. National Institute for Clinical Excellence. Guidance on the use of electroconvulsive therapy. In: Technology Appraisal 59;2003.
27. Scott AIF. The ECT Handbook: The Third Report of the Royal College of Psychiatrists’ Special Committee of ECT. RCPsych Publications; 2005.
28. Chakrabarti S, Grover S, Rajagopal R. Electroconvulsive therapy: a review of knowledge, experience and attitudes of patients concerning the treatment. World J Biol Psychiatry. 2010;11(3):525–537. PubMed CrossRef
29. Rose D, Fleischmann P, Wykes T, et al. Patients’ perspectives on electroconvulsive therapy: systematic review. BMJ. 2003;326(7403):1363. PubMed CrossRef
30. Semkovska M, McLoughlin DM. Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biol Psychiatry. 2010;68(6):568–577. PubMed CrossRef
31. Sackeim HA, Prudic J, Fuller R, et al. The cognitive effects of electroconvulsive therapy in community settings. Neuropsychopharmacology. 2007;32(1):244–254. PubMed CrossRef
32. Ward HB, Szabo ST, Rakesh G. Maintenance ECT in schizophrenia: a systematic review. Psychiatry Res. 2018;264:131–142. PubMed CrossRef
33. Ali SA, Mathur N, Malhotra AK, et al. Electroconvulsive therapy and schizophrenia: a systematic review. Mol Neuropsychiatry. 2019;5(2):75–83. PubMed
34. Zheng W, Tong G, Ungvari GS, et al. Memory impairment following electroconvulsive therapy in Chinese patients with schizophrenia: meta-analysis of randomized controlled trials. Perspect Psychiatr Care. 2018;54(2):107–114. PubMed CrossRef
35. Runck B. NIMH report. Consensus panel backs cautious use of ECT for severe disorders. Hosp Community Psychiatry. 1985;36(9):943–946. PubMed CrossRef
36. Guyatt GH, Oxman AD, Schünemann HJ, et al. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64(4):380–382. PubMed CrossRef
37. Meader N, King K, Llewellyn A, et al. A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation. Syst Rev. 2014;3:82. PubMed CrossRef
38. Jiang J, Li J, Xu Y, et al. Magnetic seizure therapy compared to electroconvulsive therapy for schizophrenia: a randomized controlled trial. Front Psychiatry. 2021;12:770647. PubMed CrossRef
39. Stryjer R, Ophir D, Bar F, et al. Rivastigmine treatment for the prevention of electroconvulsive therapy-induced memory deficits in patients with schizophrenia. Clin Neuropharmacol. 2012;35(4):161–164. PubMed CrossRef
40. Petrides G, Malur C, Braga RJ, et al. Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study. Am J Psychiatry. 2015;172(1):52–58. PubMed CrossRef
41. Yang Y, Cheng X, Xu Q, et al. The maintenance of modified electroconvulsive therapy combined with risperidone is better than risperidone alone in preventing relapse of schizophrenia and improving cognitive function. Arq Neuropsiquiatr. 2016;74(10):823–828. PubMed CrossRef
42. Bansod A, Sonavane SS, Shah NB, et al. A randomized, nonblind, naturalistic comparison of efficacy and cognitive outcomes with right unilateral, bifrontal, and bitemporal electroconvulsive therapy in schizophrenia. J ECT. 2018;34(1):26–30. PubMed
43. Chan CYW, Abdin E, Seow E, et al. Clinical effectiveness and speed of response of electroconvulsive therapy in treatment-resistant schizophrenia. Psychiatry Clin Neurosci. 2019;73(7):416–422. PubMed CrossRef
44. Chanpattana W. Maintenance ECT in treatment-resistant schizophrenia. J Med Assoc Thai. 2000;83(6):657–662. PubMed
45. Chanpattana W, Kramer BA. Acute and maintenance ECT with flupenthixol in refractory schizophrenia: sustained improvements in psychopathology, quality of life, and social outcomes. Schizophr Res. 2003;63(1–2):189–193. PubMed CrossRef
46. Davarinejad O, Hendesi K, Shahi H, et al. A pilot study on daily intensive ECT over 8 days improved positive and negative symptoms and general psychopathology of patients with treatment-resistant schizophrenia up to 4 weeks after treatment. Neuropsychobiology. 2019;77(2):83–91. PubMed CrossRef
47. Liu Y, Jia LN, Wu H, et al. Adjuvant electroconvulsive therapy with antipsychotics is associated with improvement in auditory mismatch negativity in schizophrenia. Psychiatry Res. 2022;311:114484. PubMed CrossRef
48. Mishra BR, Agrawal K, Biswas T, et al. Comparison of acute followed by maintenance ECT vs clozapine on psychopathology and regional cerebral blood flow in treatment-resistant schizophrenia: a randomized controlled trial. Schizophr Bull. 2022;48(4):814–825. PubMed CrossRef
49. Simsek GG, Zincir S, Gulec H, et al. Do ictal EEG characteristics predict treatment outcomes in schizophrenic patients undergoing electroconvulsive therapy? Nord J Psychiatry. 2015;69(6):466–471. PubMed CrossRef
50. Tan XW, Lim KWK, Martin D, et al. Effects of electroconvulsive therapy on cognition and quality of life in schizophrenia. Ann Acad Med Singap. 2022;51(7):400–408. PubMed CrossRef
51. Vuksan Ćusa B, Klepac N, Jakšić N, et al. The effects of electroconvulsive therapy augmentation of antipsychotic treatment on cognitive functions in patients with treatment-resistant schizophrenia. J ECT. 2018;34(1):31–34. PubMed
52. Wysokinski A, Dzienniak M, Kloszewska I. Assessment of cognitive performance using CNS vital signs after electroconvulsive treatment of schizophrenia. J ECT. 2014;30(1):e5–e6. PubMed
53. Niemansburg SL, van Delden JJM, Dhert WJA, et al. Reconsidering the ethics of sham interventions in an era of emerging technologies. Surgery. 2015;157(4):801–810. PubMed CrossRef
54. Kim JH, Youn T, Choi JG, et al. Combination of electroconvulsive therapy and clozapine in treatment-resistant schizophrenia. Psychiatry Investig. 2018;15(8):829–835. PubMed CrossRef
55. Pawelczyk A, Kolodziej-Kowalska E, Pawelczyk T, et al. Is there a decline in cognitive functions after combined electroconvulsive therapy and antipsychotic therapy in treatment-refractory schizophrenia? J Nerv Ment Dis. 2015;203(3):182–186. PubMed
56. Li P, Jing RX, Zhao RJ, et al. Electroconvulsive therapy-induced brain functional connectivity predicts therapeutic efficacy in patients with schizophrenia: a multivariate pattern recognition study. NPJ Schizophr. 2017;3:21. PubMed CrossRef
57. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–198. PubMed
58. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695–699. PubMed CrossRef
59. Randolph C, Tierney MC, Mohr E, et al. The repeatable Battery for the assessment of neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20(3):310–319. PubMed CrossRef
60. Kennedy JL, Altar CA, Taylor DL, et al. The social and economic burden of treatment-resistant schizophrenia: a systematic literature review. Int Clin Psychopharmacol. 2014;29(2):63–76. PubMed CrossRef
61. Correll CU, Brevig T, Brain C. Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists. BMC Psychiatry. 2019;19(1):362. PubMed CrossRef
62. Millgate E, Hide O, Lawrie SM, et al. Neuropsychological differences between treatment-resistant and treatment-responsive schizophrenia: a meta-analysis. Psychol Med. 2022;52(1):1–13.
63. Kumar S, Mulsant BH, Liu AY, et al. Systematic review of cognitive effects of electroconvulsive therapy in late-life depression. Am J Geriatr Psychiatry. 2016;24(7):547–565. PubMed CrossRef
64. UK ECT Review Group. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;361(9360):799–808. PubMed CrossRef
65. Lomas M, Rickard V, Milton F, et al. Electroconvulsive therapy related autobiographical amnesia: a review and case report. Cogn Neuropsychiatry. 2021;26(2):107–121. PubMed CrossRef
66. Lappin JM, Davies K, O’Donnell M, et al. Underuse of recommended treatments among people living with treatment-resistant psychosis. Front Psychiatry. 2022;13:987468. PubMed CrossRef
67. Wang W, Pu C, Jiang J, et al. Efficacy and safety of treating patients with refractory schizophrenia with antipsychotic medication and adjunctive electroconvulsive therapy: a systematic review and meta-analysis. Shanghai Arch Psychiatry. 2015;27(4):206–219. PubMed CrossRef
68. Grover S, Sahoo S, Rabha A, et al. ECT in schizophrenia: a review of the evidence. Acta Neuropsychiatr. 2019;31(3):115–127. PubMed CrossRef
69. Dowman J, Patel A, Rajput K. Electroconvulsive therapy: attitudes and misconceptions. J ECT. 2005;21(2):84–87. PubMed CrossRef
70. Maroney M. An update on current treatment strategies and emerging agents for the management of schizophrenia. Am J Manag Care. 2020;26(3 suppl):S55–S61. PubMed CrossRef
71. Ventura J, Thames AD, Wood RC, et al. Disorganization and reality distortion in schizophrenia: a meta-analysis of the relationship between positive symptoms and neurocognitive deficits. Schizophr Res. 2010;121(1–3):1–14. PubMed CrossRef
72. Cicek M, McCall WV, Yao Z, et al. Is there evidence that stimulus parameters and electrode placement affect the cognitive side effects of electroconvulsive therapy in patients with schizophrenia and schizoaffective disorder? a systematic review. J ECT. 2021;37(2):133–139. PubMed CrossRef