Clozapine Versus Chlorpromazine in Geriatric Patients

Letter to the Editor

Sir: I began my career in clinical research conducting multicenter
comparative drug studies of antipsychotic agents in geriatric
Veterans Affairs hospital patients. Thus, it was with high
expectations that I read the article by Howanitz et al. comparing
the old gold standard, chlorpromazine, with the new gold
standard, clozapine, in a geriatric Veterans Affairs hospital patient
population.

I was disappointed to find, however, certain problems with
the authors’ interpretations of their study results.