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In last month’s ASCP Corner, I discussed some of the challenges and recent developments regarding the available evidence base for the use of antipsychotics and mood stabilizers in children and adolescents. 1 In this month’s column, I will focus on some of the pertinent clinical psychopharmacology trials design issues that are relevant to the collection of data in children and adolescents who are in need of antipsychotic or mood stabilizer treatment.

While it is clear that studying psychotropic medication effects in children and adolescents is crucial, it is also a difficult task.’ ‹’ ‹