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Dr. Kane: We discussed the clinical relevance that the field of pharmacogenetics has for diagnosing and potentially individualizing treatment for patients with schizophrenia in Part 1 of this ACADEMIC HIGHLIGHTS. In this discussion, we will explore how pharma- cogenetics might help us to identify the relationship between schizophrenia and bipolar disorder as well as manage peripheral problems associated with schizophrenia and bipolar disorder such as cognitive dysfunction and treatment-associated side effects.