Chronic Leukocytosis Associated With Clozapine: A Case Series

Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.

Sir: The potential for clozapine, a dibenzodiazepine derivative, to cause leukopenia/agranulocytosis is well-known; however, leukocytosis associated with clozapine has been reported infrequently, particularly in the U.S. literature. Persistent clozapine-associated leukocytosis without fever or other complications is rarely reported.¹ Leukocytosis, defined as a white blood cell (WBC) count greater than 11,000/mm3 (11 ×— 109/L), is frequently found in the course of routine laboratory testing.’ ‹