Chairman's Overview/The Place of Reboxetine in Antidepressant Therapy

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A wide range of antidepressants is now availableincluding the tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), reversiblemonoamine oxidase-A inhibitors (RIMAs), serotonin selectivereuptake inhibitors (SSRIs), serotonin and norepinephrinereuptake inhibitors (SNRIs), and atypical antidepressantssuch as mirtazapine and nefazodone. However,clinicians still face a number of problems when selectingthe most appropriate antidepressant for a given patient.TCAs are effective in a wide range of patients, but they dohave significant drawbacks in terms of their tolerabilityand safety in overdose, reflecting actions at sites otherthan those involved in the antidepressant effect.