Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report

Sidney H. Kennedy, MD; Raymond W. Lam, MD; Susan Rotzinger, PhD; Roumen V. Milev, MD, PhD; Pierre Blier, MD, PhD; Jonathan Downar, MD, PhD; Kenneth R. Evans, PhD; Faranak Farzan, PhD; Jane A. Foster, PhD; Benicio N. Frey, MD, PhD; Peter Giacobbe, MD; Geoffrey B. Hall, PhD; Kate L. Harkness, PhD; Stefanie Hassel, PhD; Zahinoor Ismail, MD; Francesco Leri, PhD; Shane McInerney, MD; Glenda M. MacQueen, MD, PhD; Luciano Minuzzi, MD, PhD; Daniel J. Müller, MD, PhD; Sagar V. Parikh, MD; Franca M. Placenza, PhD; Lena C. Quilty, PhD; Arun V. Ravindran, MD, PhD; Roberto B. Sassi, MD, PhD; Claudio N. Soares, MD, PhD, MBA; Stephen C. Strother, PhD; Gustavo Turecki, MD, PhD; Anthony L. Vaccarino, PhD; Fidel Vila-Rodriguez, MD; Joanna Yu, PhD; Rudolf Uher, MD, PhD; CAN-BIND Investigator Team,

J Clin Psychiatry 2019;80(2):18m12202

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Author Affiliations

Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada
Corresponding author: Sidney H. Kennedy, MD, St Michael's Hospital, 193 Yonge St, Ste 6-001A, Toronto, ON M5B1M4, Canada ([email protected])
University of British Columbia and Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, Queen's University and Providence Care Hospital, Kingston, Ontario, Canada
Department of Psychology, Queen's University, Kingston, Ontario, Canada
University of Ottawa Institute of Mental Health Research, Ottawa, Ontario, Canada
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Indoc Research, Toronto, Ontario, Canada
Department of Pathology and Molecular Medicine, Queen’s University, Kingston, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Department of Psychology, Queen's University, Kingston, Ontario, Canada
University of Calgary, Hotchkiss Brain Institute, Calgary, Alberta, Canada
University of Calgary, Hotchkiss Brain Institute, Calgary, Alberta, Canada
University of Guelph, Guelph, Ontario, Canada
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
University of Calgary, Hotchkiss Brain Institute, Calgary, Alberta, Canada
Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
University of Michigan, Ann Arbor, Michigan
Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Department of Psychiatry, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, Queen's University and Providence Care Hospital, Kingston, Ontario, Canada
Rotman Research Institute at Baycrest Centre, Toronto, Ontario, Canada
McGill University, Montréal, Quebec, Canada
Douglas Mental Health University Institute Frank B. Common (FBC), Montréal, Quebec, Canada
Indoc Research, Toronto, Ontario, Canada
University of British Columbia and Vancouver Coastal Health Authority, Vancouver, British Columbia, Canada
Department of Psychiatry, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
Members of the CAN-BIND Investigator Team are listed at www.canbind.ca/our-team/