Bipolar Depression Associated With Fenfluramine and Phentermine

Sir: Fenfluramine and phentermine have often been used in combination for the treatment of obesity. Although the Physicians’ Desk Reference lists depression as a potential adverse effect of fenfluramine, it is not contraindicated in the treatment of patients with comorbid mood disorders. We present the case of a woman with a history of bipolar disorder who developed a major depressive episode following administration of fenfluramine and phentermine.