Beneficial Effects of Gonadotropin-Releasing Hormone Analogue Treatment on Positive and Negative Symptoms of Schizophrenia: A Case Report

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Sir: This letter reports a patient with chronic treatmentresistant schizophrenia and deviant sexual behavior who showed clinical improvement after treatment with the depot gonadotropin-releasing hormone (GnRH) analogue buserelin acetate. The patient’s clinical improvement included decrease in positive (hallucinations, disorganization) as well as negative (social withdrawal, academic interest) symptoms. The possible therapeutic and theoretical implications of the putative role of hormones in schizophrenia are briefly discussed.