Are Antidepressants Effective? What's a Clinician to Think?

Questions about the efficacy of antidepressantdrugs in depression have beenraised as a result of 2 recent reports.Turner et al. reviewed industry-sponsoredclinical trials (randomized controlled trials;RCTs) submitted to the FDA and foundthat positive RCTs were more likely to besubsequently published than negative trials.The authors suggested that publisheddata overestimate the effectiveness of antidepressants.