This article is available to members only. Please enjoy the abstract for free. Subscribe for instant access to the full article.

This content is restricted to subscribers

Continue Reading...

Did you know members enjoy unlimited free PDF downloads as part of their subscription? Subscribe today for instant access to this article and our entire library in your preferred format. Alternatively, you can purchase the PDF of this article individually.

Subscribe Now

Already a member? Login

Purchase PDF for $40

Members enjoy free PDF downloads on all articles. Join today

  1. Nîmes University Hospital, Nîmes, France; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
  2. Corresponding author: Ismael Conejero, MD, PhD, Department of Psychiatry, CHU Nîmes, Pl du Professeur Robert Debré, 30900 Nîmes, France ([email protected]).
  3. Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU Montpellier, IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
  4. Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU Montpellier, IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
  5. INSERM UMR 1027, Toulouse, France; University of Toulouse III, Toulouse, France; Gérontopôle, Department of Geriatrics, Toulouse (University Hospital) CHU, Purpan University Hospital, Toulouse, France
  6. Toulouse University Hospital, Toulouse, France; Inserm U1214, University of Toulouse III, Toulouse, France
  7. INSERM UMR 1027, Toulouse, France; University of Toulouse III, Toulouse, France; Gérontopôle, Department of Geriatrics, Toulouse (University Hospital) CHU, Purpan University Hospital, Toulouse, France
  8. Nîmes University Hospital, Nîmes, France; IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
  9. Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU Montpellier, IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
  10. Department of Neurology, Memory Research and Resources Center, Montpellier University Hospital, Montpellier, France
  11. Members are listed at the end of the article.
  1. Lyketsos CG, Olin J. Depression in Alzheimer’s disease: overview and treatment. Biol Psychiatry. 2002;52(3):243–252. PubMed CrossRef
  2. Richard E, Reitz C, Honig LH, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013;70(3):374–382. PubMed CrossRef
  3. Hargrave R, Reed B, Mungas D. Depressive syndromes and functional disability in dementia. J Geriatr Psychiatry Neurol. 2000;13(2):72–77. PubMed CrossRef
  4. Conejero I, Navucet S, Keller J, et al. A complex relationship between suicide, dementia, and amyloid: a narrative review. Front Neurosci. 2018;12:371. PubMed CrossRef
  5. Murphy MP, LeVine H 3rd. Alzheimer’s disease and the amyloid-β J Alzheimers Dis. 2010;19(1):311–323. PubMed CrossRef
  6. Querol-Vilaseca M, Colom-Cadena M, Pegueroles J, et al. Nanoscale structure of amyloid-β plaques in Alzheimer’s disease. Sci Rep. 2019;9(1):5181. PubMed CrossRef
  7. Marano C, Workman C, Lyman C, et al. Cortical beta-amyloid deposition in late-life depression. Am J Geriatr Psychiatry. 2013;21(3):S127. CrossRef
  8. Wu K-Y, Hsiao I-T, Chen C-S, et al. Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography. Eur J Nucl Med Mol Imaging. 2014;41(4):714–722. PubMed CrossRef
  9. Chung JK, Plitman E, Nakajima S, et al; Alzheimer’s Disease Neuroimaging Initiative. lifetime history of depression predicts increased amyloid-β accumulation in patients with mild cognitive impairment. J Alzheimers Dis. 2015;45(3):907–919. PubMed CrossRef
  10. Tateno A, Sakayori T, Higuchi M, et al. Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset. Int J Geriatr Psychiatry. 2015;30(7):720–728. PubMed CrossRef
  11. Li P, Hsiao I-T, Liu C-Y, et al. Beta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study. EJNMMI Res. 2017;7(1):24. PubMed CrossRef
  12. Wu K-Y, Lin K-J, Chen C-H, et al. Diversity of neurodegenerative pathophysiology in nondemented patients with major depressive disorder: evidence of cerebral amyloidosis and hippocampal atrophy. Brain Behav. 2018;8(7):e01016. PubMed CrossRef
  13. Lavretsky H, Siddarth P, Kepe V, et al. Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults. Am J Geriatr Psychiatry. 2009;17(6):493–502. PubMed CrossRef
  14. Kumar A, Kepe V, Barrio JR, et al. Protein binding in patients with late-life depression. Arch Gen Psychiatry. 2011;68(11):1143–1150. PubMed CrossRef
  15. Madsen K, Hasselbalch BJ, Frederiksen KS, et al. Lack of association between prior depressive episodes and cerebral [11C]PiB binding. Neurobiol Aging. 2012;33(10):2334–2342. PubMed CrossRef
  16. Yasuno F, Kazui H, Morita N, et al. High amyloid-β deposition related to depressive symptoms in older individuals with normal cognition: a pilot study. Int J Geriatr Psychiatry. 2016;31(8):920–928. PubMed CrossRef
  17. Donovan NJ, Locascio JJ, Marshall GA, et al; Harvard Aging Brain Study. Longitudinal association of amyloid beta and anxious-depressive symptoms in cognitively normal older adults. Am J Psychiatry. 2018;175(6):530–537. PubMed CrossRef
  18. Harrington KD, Lim YY, Gould E, et al. Amyloid-beta and depression in healthy older adults: a systematic review. Aust N Z J Psychiatry. 2015;49(1):36–46. PubMed CrossRef
  19. Vellas B, Carrie I, Gillette-Guyonnet S, et al. MAPT study: a multidomain approach for preventing Alzheimer’s disease: design and baseline data. J Prev Alzheimers Dis. 2014;1(1):13–22. PubMed
  20. Andrieu S, Guyonnet S, Coley N, et al; MAPT Study Group. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017;16(5):377–389. PubMed CrossRef
  21. Vinkers DJ, Gussekloo J, Stek ML, et al. The 15-item Geriatric Depression Scale (GDS-15) detects changes in depressive symptoms after a major negative life event: the Leiden 85-plus Study. Int J Geriatr Psychiatry. 2004;19(1):80–84. PubMed CrossRef
  22. Katz S, Ford AB, Moskowitz RW, et al. The index of ADL: a standardized measure of biological and psychosocial function. JAMA. 1963;185(12):914–919. PubMed CrossRef
  23. Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982-1983;17(1):37–49. PubMed CrossRef
  24. Marc LG, Raue PJ, Bruce ML. Screening performance of the 15-item Geriatric Depression Scale in a diverse elderly home care population. Am J Geriatr Psychiatry. 2008;16(11):914–921. PubMed CrossRef
  25. Wancata J, Alexandrowicz R, Marquart B, et al. The criterion validity of the Geriatric Depression Scale: a systematic review. Acta Psychiatr Scand. 2006;114(6):398–410. PubMed CrossRef
  26. Bleecker ML, Bolla-Wilson K, Kawas C, et al. Age-specific norms for the Mini-Mental State Exam. Neurology. 1988;38(10):1565–1568. PubMed CrossRef
  27. Hughes CP, Berg L, Danziger WL, et al. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140(6):566–572. PubMed CrossRef
  28. Friedman B, Heisel MJ, Delavan RL. Psychometric properties of the 15-item Geriatric Depression Scale in functionally impaired, cognitively intact, community-dwelling elderly primary care patients. J Am Geriatr Soc. 2005;53(9):1570–1576. PubMed CrossRef
  29. Pruessner JC, Baldwin MW, Dedovic K, et al. Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood. Neuroimage. 2005;28(4):815–826. PubMed CrossRef
  30. Orth U, Robins RW, Widaman KF. Life-span development of self-esteem and its effects on important life outcomes. J Pers Soc Psychol. 2012;102(6):1271–1288. PubMed CrossRef
  31. Orth U, Robins RW, Trzesniewski KH, et al. Low self-esteem is a risk factor for depressive symptoms from young adulthood to old age. J Abnorm Psychol. 2009;118(3):472–478. PubMed CrossRef
  32. Sowislo JF, Orth U. Does low self-esteem predict depression and anxiety? a meta-analysis of longitudinal studies. Psychol Bull. 2013;139(1):213–240. PubMed CrossRef
  33. Bothwell R, Scott J. The influence of cognitive variables on recovery in depressed inpatients. J Affect Disord. 1997;43(3):207–212. PubMed CrossRef
  34. Liu SY, Wrosch C, Miller GE, et al. Self-esteem change and diurnal cortisol secretion in older adulthood. Psychoneuroendocrinology. 2014;41:111–120. PubMed CrossRef
  35. Eberl C, Winkler I, Pawelczack S, et al. Self-esteem consistency predicts the course of therapy in depressed patients. PLoS One. 2018;13(7):e0199957. PubMed CrossRef
  36. Wagner J, Gerstorf D, Hoppmann C, et al. The nature and correlates of self-esteem trajectories in late life. J Pers Soc Psychol. 2013;105(1):139–153. PubMed CrossRef
  37. Wagner J, Hoppmann C, Ram N, et al. Self-esteem is relatively stable late in life: the role of resources in the health, self-regulation, and social domains. Dev Psychol. 2015;51(1):136–149. PubMed CrossRef
  38. Mori T, Shimada H, Shinotoh H, et al. Apathy correlates with prefrontal amyloid β deposition in Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2014;85(4):449–455. PubMed CrossRef
  39. Marshall GA, Donovan NJ, Lorius N, et al. Apathy is associated with increased amyloid burden in mild cognitive impairment. J Neuropsychiatry Clin Neurosci. 2013;25(4):302–307. PubMed CrossRef
  40. Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997;48(suppl 6):S10–S16. PubMed CrossRef
  41. Incalzi RA, Cesari M, Pedone C, et al. Construct validity of the 15-item Geriatric Depression Scale in older medical inpatients. J Geriatr Psychiatry Neurol. 2003;16(1):23–28. PubMed CrossRef
  42. Copeland JR, Beekman AT, Braam AW, et al. Depression among older people in Europe: the EURODEP studies. World Psychiatry. 2004;3(1):45–49. PubMed
  43. de Sousa RD, Rodrigues AM, Gregório MJ, et al. Anxiety and depression in the Portuguese older adults: prevalence and associated factors. Front Med (Lausanne). 2017;4:196. PubMed CrossRef
  44. Thompson LI, Jones RN. Depression screening in cognitively normal older adults: measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex. Alzheimers Dement (Amst). 2020;12(1):e12107. PubMed CrossRef