Mood Disorders

Mood disorders, encompassing conditions like bipolar disorder and major depressive disorder, are complex and multifaceted. The Journal of Clinical Psychiatry offers comprehensive insights, from understanding their etiology to evidence-based therapeutic strategies. Our expert editors ensure content is clinically relevant, providing psychiatrists with the tools they need to offer effective and compassionate care to those grappling with mood disturbances.

Recently published article about Mood Disorders

The Weekly Mind Reader: Fast New Mood Screener

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The Weekly Mind Reader: Fast New Mood Screener

April 28, 2023

The new Rapid Mood Screener can quickly and easily assess whether or not a patient's depression is associated with bipolar disorder.

Transdiagnostic PRS Prediction of Mood Disorders

Transdiagnostic PRS Prediction of Mood Disorders

April 20, 2022

Mood disorders often co-occur with behavior disorders in children and adolescents. This study explored if polygenic risk scores based on external genome-wide association studies of these disorders could improve...

Impact of Childhood Trauma History vs Recent Trauma Symptoms on Affective Lability in Bipolar Disorder

August 17, 2021

This study examined childhood trauma and current traumatic stress ratings in bipolar and unipolar inpatients to see if higher levels of childhood trauma and current trauma symptoms are associated...

A Comment on Clozapine-Induced Enuresis

January 14, 2021

In this letter to the editor, Dr Naguy comments on a report previously published in the PCC.

Modifying Clozapine Dose After Development of Pneumonia

January 7, 2021

This case report describes a patient who developed pneumonia during the course of clozapine treatment that abated after temporary cessation of clozapine and subsequent reintroduction at a lower dose.

Graphorrhea and Vortioxetine-Induced Bipolar Mood Disorder

September 10, 2020

Read a case of the antidepressant, Vortioxetine, which induced mania, causing graphorrhea in a bipolar patient.

Recent JCP Articles on Mood Disorders

Dried Blood Spot Analysis for Drug Monitoring of Clozapine

October 24, 2017

Therapeutic drug monitoring during clozapine therapy can be inconvenient as well as uncomfortable for patients. This study tested a novel method of dried blood spot (finger prick) monitoring as...

Clozapine and Blood Monitoring—Is Less Better?

July 18, 2017

In 2015, the FDA removed WBC monitoring altogether and reduced the threshold for ANCs before interruption of clozapine treatment was required. The current study looks at almost 250 clozapine-treated...

Mood Disorders and Antipsychotic Treatment in Youth

March 29, 2017

The increasing overlap of mood disorders and antipsychotic use in youth is a growing area of concern. This meta-analysis examined the current findings on the frequency of mood disorders...

Recent PCC Articles on Mood Disorders

Incidence of Obstructive Sleep Apnea With PTSD and Mood Disorders

August 9, 2018

Do you screen for sleep disorders in patients with psychiatric conditions? Symptom overlap can mean that sleep disorders such as obstructive sleep apnea are overlooked in patients with posttraumatic...

Unexpected Falls, Clozapine Treatment, and Myoclonus

January 18, 2018

Clozapine can cause falls due to orthostatic hypotension or sedation, particularly in geriatric patients. A less-recognized cause of falls in clozapine patients is myoclonus, which manifests as knee buckling...

Agranulocytosis Isn' t the Only Side Effect

August 10, 2017

Clozapine use can produce another side effect in some patients: elevated CPK. But when nothing else works and the patient finally shows response, should you risk a rechallenge even...

Featured Mood Disorders Research

Clozapine-Induced Myocarditis Screening Protocol

August 3, 2017

Clinicians should be able to recognize and manage potential side effects of clozapine, including myocarditis. However, treatment guidelines do not currently recommend a monitoring protocol for clozapine-induced myocarditis. This...

Clozapine-Induced Procalcitonin Elevation

June 15, 2017

Clozapine is the only antipsychotic approved for treatment-resistant schizophrenia; however, its use is limited due to potentially life-threatening side effects. Here, read the first report of an association between...

Two Strategies for Switching to Clozapine

February 22, 2017

What's the best way to switch to clozapine in patients with treatment-resistant schizophrenia? Do you worry that efficacy and tolerability will be compromised? This pilot, double-blind RCT addresses your...

Mania Precipitated by COVID-19 Pandemic-Related Stress

June 4, 2020

The COVID-19 pandemic is a significant psychological stressor, impacting every facet of life. Here, read the case of a 37-year-old woman who developed mania, which was precipitated by stress...

Deep Brain Stimulation in Refractory OCD

May 26, 2020

First-line treatments for OCD include selective serotonin reuptake inhibitors and cognitive-behavioral therapy. But what do you do when patients do not respond to these or second-line strategies? In this...

Mood Stabilizers and Placenta-Mediated Complications

June 18, 2019

Women who take mood stabilizers have a greater risk of placenta-mediated pregnancy complications. But are the mood stabilizers themselves responsible for this higher risk? This study explores that question.

Delirium and Dysarthria After Titration of Clozapine

May 2, 2019

Clozapine is essential for the management of treatment-refractory schizophrenia, but its use is often limited by side effects. Read this report of a man who developed dysarthria and delirium...

Olanzapine-Induced Fever

February 28, 2019

Does olanzapine induce fever in some patients? Read this case report to find out more.

Long-Term Remission With Cariprazine in Patients With Schizophrenia

January 8, 2019

When treating patients with schizophrenia, achieving stable, long-term remission is an important step toward the goal of functional recovery. This study evaluated the effect of cariprazine on several measures...

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