Stephen M. Stahl | Psychiatrist.com

Brainstorms

The 7 Habits of Highly Effective Psychopharmacologists, Part 2: Begin With the End in Mind

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The 7 Habits of Highly Effective Psychopharmacologists, Part 3: Sharpen the Saw With Selective Choices of Continuing Medical Education Programs

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The 7 Habits of Highly Effective Psychopharmacologists, Part 4: Developing and Implementing the Vision

Original Research

Agomelatine in the Treatment of Major Depressive Disorder: An 8-Week, Multicenter, Randomized, Placebo-Controlled Trial

Brainstorms

Anticonvulsants as Anxiolytics, Part 1: Tiagabine and Other Anticonvulsants With Actions on GABA

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Anticonvulsants as Mood Stabilizers and Adjuncts to Antipsychotics: Valproate, Lamotrigine, Carbamazepine, Oxcarbazepine and Actions at Voltage-Gated Sodium Channels

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Antidepressants: The Blue-Chip Psychotropic for the Modern Treatment of Anxiety Disorders

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Antidepressants and Somatic Symptoms: Therapeutic Actions Are Expanding Beyond Affective Spectrum Disorders to Functional Somatic Syndromes

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Antipsychotic Polypharmacy, Part 1: Therapeutic Option or Dirty Little Secret?

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Antipsychotic Polypharmacy, Part 2: Tips on Use and Misuse

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Antipsychotic Polypharmacy: Squandering Precious Resources?

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Apoptosis: Neuronal Death by Design

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How to Appease the Appetite of Psychotropic Drugs

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Are Two Antidepressant Mechanisms Better Than One?

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Awakening to the Psychopharmacology of Sleep and Arousal: Novel Neurotransmitters and Wake-Promoting Drugs

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"Awakening" From Schizophrenia: Intramolecular Polypharmacy and the Atypical Antipsychotics

Article

Basic Psychopharmacology of Antidepressants, Part 1: Antidepressants Have Seven Distinct Mechanisms of Action

Article

Basic Psychopharmacology of Antidepressants, Part 2: Estrogen as an Adjunct to Antidepressant Treatment

Brainstorms

Blue Genes and the Mechanism of Action of Antidepressants

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Blue Genes and the Monoamine Hypothesis of Depression

Article

Brain Circuits Determine Destiny in Depression: A Novel Approach to the Psychopharmacology of Wakefulness, Fatigue, and Executive Dysfunction in Major Depressive Disorder

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Brain Fumes: Yes, We Have NO Brain Gas

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Brainstorms: Anticonvulsants as Anxiolytics, Part 2: Pregabalin and Gabapentin as α2Î´ Ligands at Voltage-Gated Calcium Channels

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Brainstorms: Anticonvulsants and the Relief of Chronic Pain: Pregabalin and Gabapentin as α2Î´ Ligands at Voltage-Gated Calcium Channels

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Brainstorms: Mechanism of Action of α2Î´ Ligands: Voltage Sensitive Calcium Channel (VSCC) Modulators

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Brain Tonics for Brain Sprouts: How Neurotrophic Factors Fertilize Neurons

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The New Cholinesterase Inhibitors for Alzheimer's Disease, Part 1: Their Similarities Are Different

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The New Cholinesterase Inhibitors for Alzheimer's Disease, Part 2: Illustrating Their Mechanisms of Action

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HSDD: Circuits of Sexual Desire/Inhibition

Understand what is Hypoactive Sexual Desire Disorder (HSDD) and what mesolimbic and hypothalamic circuits are turned on by sexual desire/inhibition.

Original Research

Co-Use of Donepezil and Hypnotics Among Alzheimer's Disease Patients Living in the Community

Brainstorms

Combining Antidepressant Therapies From the Initiation of Treatment: A Paradigm Shift for Major Depression

Article

Debate and Discussion: Do Some Antidepressants Have a Faster Onset of Action Than Others?

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Deconstructing Psychiatric Disorders, Part 2: An Emerging, Neurobiologically Based Therapeutic Strategy for the Modern Psychopharmacologist

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Deconstructing Psychiatric Disorders, Part 1: Genotypes, Symptom Phenotypes, and Endophenotypes

Article

Development of New Antidepressants

Article

Differences in Mechanism of Action Between Current and Future Antidepressants

Brainstorms

Does Depression Hurt?

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Does Evidence From Clinical Trials in Psychopharmacology Apply in Clinical Practice?

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Don't Ask, Don't Tell, but Benzodiazepines Are Still the Leading Treatments for Anxiety Disorder

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Dopamine System Stabilizers, Aripiprazole, and the Next Generation of Antipsychotics, Part 1: "Goldilocks" Actions at Dopamine Receptors

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Dopamine System Stabilizers, Aripiprazole, and the Next Generation of Antipsychotics, Part 2: Illustrating Their Mechanism of Action

Original Research

A Double-Blind, Placebo-Controlled Study Comparing the Effects of Sertraline Versus Amitriptyline in the Treatment of Major Depression

Brainstorms

Drug Combinations for Bipolar Spectrum Disorders: Evidence-Based Prescribing or Prescribing-Based Evidence?

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New Drug Discovery in the Postgenomic Era: From Genomics to Proteomics

Original Research

Effect of Adjunctive l-Methylfolate 15 mg Among Inadequate Responders to SSRIs in Depressed Patients Who Were Stratified by Biomarker Levels and Genotype: Results From a Randomized Clinical Trial

Original Research

Effectiveness of Lurasidone for Patients With Schizophrenia Following 6 Weeks of Acute Treatment With Lurasidone, Olanzapine, or Placebo: A 6-Month, Open-Label, Extension Study

Brainstorms

Effects of Estrogen on the Central Nervous System.

Original Research

Efficacy of Bupropion and the Selective Serotonin Reuptake Inhibitors in the Treatment of Major Depressive Disorder With High Levels of Anxiety (Anxious Depression): A Pooled Analysis of 10 Studies

Brainstorms

Epigenetics and Methylomics in Psychiatry

Original Research

Escitalopram in the Treatment of Panic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial

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Estrogen Makes the Brain a Sex Organ

Article

Evidence of Early Onset of Antidepressant Effect in Randomized Controlled Trials

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Excitotoxicity and Neuroprotection

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Fibromyalgia: The Enigma and the Stigma.

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Getting Stoned Without Inhaling: Anandamide Is the Brain's Natural Marijuana

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Gut Feelings About Irritable Bowel Syndrome

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The 7 Habits of Highly Effective Psychopharmacologists: Overview

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Here Today and Not Gone Tomorrow: The Curse of Chronic Pain and Other Central Sensitization Syndromes

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"Hit-and-Run" Actions at Dopamine Receptors, Part 2: Illustrating Fast Dissociation From Dopamine Receptors That Typifies Atypical Antipsychotics

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"Hit-and-Run" Actions at Dopamine Receptors, Part 1: Mechanism of Action of Atypical Antipsychotics

Article

An Ideal Trial to Test Differential Onset of Antidepressant Effect

Brainstorms

Illustrating the Circuits of Sexual Desire

Brainstorms

Independent Actions on Fear Circuits May Lead to Therapeutic Synergy for Anxiety When Combining Serotonergic and GABAergic Agents

Article

Introduction. What Makes an Antipsychotic Atypical?

Article

Introduction: Optimizing Wakefulness in Patients With Fatigue and Executive Dysfunction

Brainstorms

Is Psychopharmacologic "Inoculation" Effective in Preventing Posttraumatic Stress Disorder?

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Molecular Neurobiology for Practicing Psychiatrists, Part 5: How a Leucine Zipper Can Turn On Genes: Immediate-Early Genes Activate Late-Gene Expression in the Brain

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L-Methylfolate: A Vitamin for Your Monoamines

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At Long Last, Long-Lasting Psychiatric Medications: An Overview of Controlled-Release Technologies

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What Makes an Antipsychotic Atypical?

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Mechanism of Action of α2A-Adrenergic Agonists in Attention-Deficit/Hyperactivity Disorder With or Without Oppositional Symptoms

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Mechanism of Action of Stimulants in Attention-Deficit/Hyperactivity Disorder

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Mechanism of Action of Voltage Sensitive Sodium Channel Modulators

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Mental Illness May Be Damaging to Your Brain

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Mergers and Acquisitions Among Psychotropics: Antidepressant Takeover of Anxiety May Now Be Complete

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Molecular Neurobiology for Practicing Psychiatrists, Part 4: Transferring the Message of Chemical Neurotransmission From Presynaptic Neurotransmitter to Postsynaptic Gene Expression

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"The Metabolic Syndrome": Psychopharmacologists Should Weigh the Evidence for Weighing the Patient

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Mirror, Mirror on the Wall, Which Enantiomer Is Fairest of Them All?

Article

Mixed Depression and Anxiety: Serotonin1A Receptors as a Common Pharmacologic Link

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Molecular Neurobiology for Practicing Psychiatrists, Part 1: Overview of Gene Activation by Neurotransmitters

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Molecular Neurobiology for Practicing Psychiatrists, Part 2: How Neurotransmitters Activate Second Messenger Systems

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Natural Estrogen as an Antidepressant for Women

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Neuropharmacology of Obesity: My Receptors Made Me Eat It

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Neurotransmission of Cognition, Part 1: Dopamine Is a Hitchhiker in Frontal Cortex: Norepinephrine Transporters Regulate Dopamine

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Neurotransmission of Cognition, Part 3. Mechanism of Action of Selective NRIs: Both Dopamine and Norepinephrine Increase in Prefrontal Cortex

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Neurotransmission of Cognition, Part 2 Selective NRIs Are Smart Drugs: Exploiting Regionally Selective Actions on Both Dopamine and Norepinephrine to Enhance Cognition

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When Neurotrophic Factors Get on Your Nerves: Therapy for Neurodegenerative Disorders

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Nitric Oxide Physiology and Pharmacology

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Norepinephrine and Dopamine Regulate Signals and Noise in the Prefrontal Cortex

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Paying Attention to Your Acetylcholine, Part 2: The Function of Nicotinic Receptors

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Paying Attention to Your Acetylcholine, Part 1: Structural Organization of Nicotinic Receptors

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Peptides and Psychiatry, Part 3: Substance P and Serendipity: Novel Psychotropics Are a Possibility

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Peptides and Psychiatry, Part 1: How Synthesis of Neuropeptides Differs From Classical Neurotransmitter Synthesis

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Preemptive Analgesia: Is Pain Less Costly When You Pre-Pay For It?

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The Prefrontal Cortex Is Out of Tune in Attention-Deficit/Hyperactivity Disorder

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Prophylactic Antipsychotics: Do They Keep You From Catching Schizophrenia?

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How Psychiatrists Can Build New Therapies for Impotence

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Can Psychopharmacologic Treatments That Relieve Symptoms Also Prevent Disease Progression?

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Psychopharmacology of Anticonvulsants: Do All Anticonvulsants Have the Same Mechanism of Action?

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Psychopharmacology of Anticonvulsants: Levetiracetam as a Synaptic Vesicle Protein Modulator

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The Psychopharmacology of Energy and Fatigue

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The Psychopharmacology of Painful Physical Symptoms in Depression

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The Psychopharmacology of Sex, Part 2: Effects of Drugs and Disease on the 3 Phases of Human Sexual Response

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The Psychopharmacology of Sex, Part 1: Neurotransmitters and the 3 Phases of the Human Sexual Response

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Psychopharmacology of Wakefulness: Pathways and Neurotransmitters

Article

The Psychopharmacology of Ziprasidone: Receptor-Binding Properties and Real-World Psychiatric Practice

Brainstorms

Recognition Molecules Are Trailblazers for Axon Pathways

Original Research

Reemergence of Sexual Dysfunction in Patients With Major Depressive Disorder: Double-Blind Comparison of Nefazodone and Sertraline

Letter to the Editor

Reply to A Different Mechanism to Understand Activation/Sedation Side Effects of Ziprasidone

Letter to the Editor

Reply to Folate Supplementation: Is It Safe and Effective?

Letter to the Editor

Reply to Letter to the Editor "Combination Therapy: Is Clinical Practice Leading the Way?"

Letter to the Editor

Reply to Letter to the Editor "Gold Versus Silver: The Issue of Functional Versus Symptomatic Recovery in Depression"

Letter to the Editor

Reply to Letter to the Editor "Polypharmacy of 2 Atypical Antipsychotics"

Letter to the Editor

Reply to Polypharmacy in Schizophrenia: A Fuzzy Concept

Original Research

Risperidone and Paroxetine Given Singly and in Combination for Bipolar Depression

Brainstorms

Molecular Neurobiology for Practicing Psychiatrists, Part 3: How Second Messengers "Turn On" Genes by Activating Protein Kinases and Transcription Factors

Article

Selecting an Antidepressant by Using Mechanism of Action to Enhance Efficacy and Avoid Side Effects

Article

Selecting an Atypical Antipsychotic by Combining Clinical Experience With Guidelines From Clinical Trials

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Selective Actions on Sleep or Anxiety by Exploiting GABA-A/Benzodiazepine Receptor Subtypes

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Not So Selective Serotonin Reuptake Inhibitors

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Serotonin: It's Possible to Have Too Much of a Good Thing

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The Serotonin-7 Receptor as a Novel Therapeutic Target

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Sex Therapy in Psychiatric Treatment Has a New Partner: Reproductive Hormones

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The Sigma Enigma: Can Sigma Receptors Provide a Novel Target for Disorders of Mood and Cognition?

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Substance P and the Neurokinins: Novel Peptide Neurotransmitters in Psychopharmacology

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Symptoms and Circuits, Part 2: Anxiety Disorders

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Symptoms and Circuits, Part 1: Major Depressive Disorder

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Symptoms and Circuits, Part 3: Schizophrenia

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Targeting Circuits of Sexual Desire as a Treatment Strategy for Hypoactive Sexual Desire Disorder

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The Ups and Downs of Novel Antiemetic Drugs, Part 2: An Illustration

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The Ups and Downs of Novel Antiemetic Drugs, Part 1: Substance P, 5-HT, and the Neuropharmacology of Vomiting

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Using Secondary Binding Properties to Select a Not So Selective Serotonin Reuptake Inhibitor

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Vasomotor Symptoms and Depression in Women, Part 1. Role of Vasomotor Symptoms in Signaling the Onset or Relapse of a Major Depressive Episode

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Vasomotor Symptoms and Depression in Women, Part 2. Treatments That Cause Remission and Prevent Relapses of Major Depressive Episodes Overlap With Treatments for Vasomotor Symptoms

Original Research

The Vasopressin V1b Receptor Antagonist SSR149415 in the Treatment of Major Depressive and Generalized Anxiety Disorders: Results From 4 Randomized, Double-Blind, Placebo-Controlled Studies

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Why Drugs and Hormones May Interact in Psychiatric Disorders

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Why Settle for Silver, When You Can Go for Gold? Response vs. Recovery as the Goal of Antidepressant Therapy.

Original Research

A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor

Academic Highlights

Using Atypical Antipsychotics in Primary Care

Original Research

15 Years of Clinical Experience With Bupropion HCl: From Bupropion to Bupropion SR to Bupropion XL

Article

Describing an Atypical Antipsychotic: Receptor Binding and Its Role in Pathophysiology

Article

Brain Circuits Determine Destiny in Depression: A Novel Approach to the Psychopharmacology of Wakefulness, Fatigue, and Executive Dysfunction in Major Depressive Disorder

Article

Introduction: Optimizing Wakefulness in Patients With Fatigue and Executive Dysfunction

Article

Selecting an Antidepressant by Using Mechanism of Action to Enhance Efficacy and Avoid Side Effects

Original Research

The Effectiveness of St. John's Wort in Major Depressive Disorder: A Naturalistic Phase 2 Follow-Up in Which Nonresponders Were Provided Alternate Medication

Original Research

Need for New Atypical Antipsychotic Nomenclature

The current nomenclature for atypical antipsychotics does not convey that they are frequently prescribed to treat nonpsychotic indications, such as bipolar I mania, bipolar I depression, and MDD.

Original Research

Screening for Bipolar Disorder and Evaluating the RMS

Health care providers found the Rapid Mood Screener, a new bipolar I disorder screening tool, to be superior to the widely used Mood Disorder Questionnaire in sensitivity/specificity, brevity, practicality,...

Original Research

Efficacy of Lumateperone in Bipolar Depression With Mixed Features

Lumateperone significantly improved depression symptoms, disease severity, and quality of life in patients with bipolar depression with mixed features.

Original Research

Efficacy and Safety of Iloperidone in Bipolar Mania

At 4 weeks of treatment, patients receiving iloperidone showed significant improvement on the Young Mania Rating Scale versus those receiving placebo.

Original Research

Esmethadone in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.