Cedric O’Gorman

Altered glutamatergic neurotransmission has been implicated in the pathogenesis of depression. This phase 3 trial evaluated the efficacy and safety of AXS-05 (dextromethorphan-bupropion) in the treatment of major depressive...

Although this trial of esmethadone did not meet its primary outcome, some secondary and post hoc outcomes were promising.